{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:41:35Z","timestamp":1788234095794,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have associated the involvement of xanthine oxidase (<jats:styled-content style=\"fixed-case\">XO<\/jats:styled-content>) activity, a source of uric acid and reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>), to pro\u2010oxidative and pro\u2010inflammatory effects during pathological conditions. Considering this, the aim of this study was to evaluate whether upregulation on seric <jats:styled-content style=\"fixed-case\">XO<\/jats:styled-content> activity may be a pathway involved in the oxidative stress in fish exposed to a diet contaminated with aflatoxin B<jats:sub>1<\/jats:sub> (<jats:styled-content style=\"fixed-case\">AFB<\/jats:styled-content><jats:sub>1<\/jats:sub>), as well as whether it may be considered a pathway involved in <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>x production. Xanthine oxidase activity, as well as the uric acid, <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>x levels increased in serum of fish fed with a <jats:styled-content style=\"fixed-case\">AFB<\/jats:styled-content><jats:sub>1<\/jats:sub>\u2010contaminated diet on days 14 and 21 post\u2010feeding compared to fish fed with a basal diet. Based on these evidences, upregulation of seric <jats:styled-content style=\"fixed-case\">XO<\/jats:styled-content> activity induces pro\u2010oxidant and pro\u2010inflammatory profiles in serum of fish fed with a <jats:styled-content style=\"fixed-case\">AFB<\/jats:styled-content><jats:sub>1<\/jats:sub>\u2010contaminated diet due to excessive formation on uric acid. Also, the excessive uric acid induces the release of pro\u2010oxidant and pro\u2010inflammatory mediators, as <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>x, also contributing to oxidative and inflammatory profiles. In summary, the upregulation on seric <jats:styled-content style=\"fixed-case\">XO<\/jats:styled-content> activity may be considered a pathway involved in the oxidative stress of fish exposed to a diet contaminated with <jats:styled-content style=\"fixed-case\">AFB<\/jats:styled-content><jats:sub>1<\/jats:sub>.<\/jats:p>","DOI":"10.1111\/jfd.12812","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T11:45:07Z","timestamp":1525952707000},"page":"1153-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Xanthine oxidase activity exerts pro\u2010oxidative and pro\u2010inflammatory effects in serum of silver catfish fed with a diet contaminated with aflatoxin B<sub>1<\/sub>"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-8528","authenticated-orcid":false,"given":"M D","family":"Baldissera","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology Universidade Federal de Santa Maria Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-0454","authenticated-orcid":false,"given":"C F","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Universidade Federal de Santa Maria Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Doleski","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Universidade Federal de Santa Maria Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C C","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Universidade Federal de Santa Maria Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Descovi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Universidade Federal de Santa Maria Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00a0S","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Department of Animal Science Universidade do Estado de Santa Catarina Chapec\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-0100","authenticated-orcid":false,"given":"B","family":"Baldisserotto","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Universidade Federal de Santa Maria Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejar.2017.09.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.12.012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00053"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2015.08.022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12709"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2017.04.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/2008-6970-5-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3527579"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-84782010001000009"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.01.022"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejar.2015.11.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-015-0164-4"},{"key":"e_1_2_5_14_1","first-page":"1111","article-title":"Chemoprevention and therapeutic efficacy of glutathione against aflatoxicosis in Nile Tilapia (Oreochromis niloticus)","volume":"13","author":"El\u2010Barbary M. 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