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The disease affects all life stages, both in hatcheries and after release into salmon cages. Therefore, it is important to establish robust challenge models, to be used for vaccine development. Exposure experiments via intramuscular and intraperitoneal injection underlined the high virulence of the bacteria, whereas the cohabitation and bath models allowed the chronic symptoms of the disease to be studied more accurately. Skin lesions and haemorrhage at the base of fins were observed in the more acute cases of the disease. Symptoms including white spots over the skin, especially around the eyes, characterized the chronic cases. The latter were most prominent from the bath challenge model. Histopathology indicated a systemic pattern of disease, whereas <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> analysis from head kidney showed that bacteria may be present in survivor fish at the end of the challenges. In all the challenge models investigated, <jats:italic>Pasteurella<\/jats:italic> sp. was re\u2010isolated from the fish, thus fulfilling Koch's postulates. These findings highlight the importance of screening of lumpsuckers prior to transfer to minimize the risks of carrying over asymptomatic carriers.<\/jats:p>","DOI":"10.1111\/jfd.12905","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T11:46:01Z","timestamp":1539344761000},"page":"35-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pathogenicity of <i>Pasteurella<\/i> sp. in lumpsuckers (<i>Cyclopterus lumpus<\/i> L.)"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-4017","authenticated-orcid":false,"given":"Rebecca Marie","family":"Ellul","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilie","family":"Walde","sequence":"additional","affiliation":[{"name":"Department of Aquatic Animal Health Norwegian Veterinary Institute Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-9214","authenticated-orcid":false,"given":"Gyri Teien","family":"Haugland","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun","family":"Wergeland","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"R\u00f8nneseth","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12366"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.01884-0"},{"key":"e_1_2_7_4_1","first-page":"70","volume-title":"Fish health report: 2015","author":"Born\u00f8 G.","year":"2016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/f75-279"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-41-2-240"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3147\/jsfp.31.33"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90197-7"},{"key":"e_1_2_7_9_1","first-page":"97","volume-title":"Fish health report: 2017","author":"Gulla S.","year":"2018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12420"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047909"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao019161"},{"key":"e_1_2_7_13_1","volume-title":"Farmed fish health report 2012","author":"Johansen R.","year":"2013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-7345.2000.tb00355.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8667(1992)004<0227:CSOCCI>2.3.CO;2"},{"key":"e_1_2_7_16_1","volume-title":"Stamfisk screening. 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