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Following the ban of malachite green in food fish production, the demand for new treatments pushes towards the selection of more safe and environment\u2010friendly products. In the present work, in vitro activity of ten chemicals and three commercial products was tested on different strains of <jats:italic>Saprolegnia<\/jats:italic>, using malachite green as reference compound. The compounds were screened in agar and in water to assess the minimum inhibitory concentration (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>) and the minimum lethal concentration (<jats:styled-content style=\"fixed-case\">MLC<\/jats:styled-content>), respectively. Two strains of <jats:italic>Saprolegnia parasitica<\/jats:italic> and one isolate of <jats:italic>Saprolegnia delica<\/jats:italic> were tested in triplicate per each concentration. Among tested chemicals, benzoic acid showed the lowest <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> (100\u00a0ppm) followed by acetic acid, iodoacetic acid and copper sulphate (250\u00a0ppm). Sodium percarbonate was not effective at any tested concentration. Among commercial products, Virkon<jats:sup>\u2122<\/jats:sup>S was effective in inhibiting the growth of the mycelium (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>\u00a0=\u00a0<jats:styled-content style=\"fixed-case\">MLC<\/jats:styled-content>\u00a0=\u00a01,000\u00a0ppm). Actidrox\u00ae and Detarox\u00ae <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> showed <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>\u00a0=\u00a05,000 and 1,000\u00a0ppm, respectively, while <jats:styled-content style=\"fixed-case\">MLC<\/jats:styled-content>s were 10\u2010fold lower than <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>s, possibly due to a higher activity of these products in water. Similarly, a higher effectiveness in water was observed also for iodoacetic acid.<\/jats:p>","DOI":"10.1111\/jfd.12923","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T10:09:44Z","timestamp":1544436584000},"page":"237-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["In vitro activity of chemicals and commercial products against <i>Saprolegnia parasitica<\/i> and <i>Saprolegnia delica<\/i> strains"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-9929","authenticated-orcid":false,"given":"Perla","family":"Tedesco","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Ozzano Emilia (BO) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Fioravanti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Ozzano Emilia (BO) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Galuppi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences Alma Mater Studiorum University of Bologna  Ozzano Emilia (BO) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"45","article-title":"The persistence of malachite green in the edible tissue of rainbow trout (Oncorhynchus mykiss)","volume":"32","author":"Alborali L.","year":"1997","journal-title":"Rivista Italiana di Acquacoltura"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1985.tb00945.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2761.1986.tb01030.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091878"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0981-9428(02)01470-5"},{"key":"e_1_2_7_7_1","unstructured":"Bailey T. 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