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The myxozoan parasites invade the intestinal mucosa, causing a cachectic syndrome associated with intestinal barrier alteration; nonetheless, their pathological impact is different. Turbot infected by <jats:italic>Enteromyxum scophthalmi<\/jats:italic> develop more severe intestinal lesions, reaching mortality rates of 100%, whereas in <jats:italic>E.\u00a0leei<\/jats:italic>\u2010infected gilthead sea bream, the disease progresses slowly, and mortality rates are lower. The mechanisms underlying the different pathogenesis are still unclear. We studied the distribution and expression changes of E\u2010cadherin, a highly conserved protein of the adherens junctions, in the intestine of both species by immunohistochemistry and quantitative PCR, using the same immunohistochemical protocol and common primers. The regular immunostaining pattern observed in control fish turned into markedly irregular in parasitized turbot, showing an intense immunoreaction at the host\u2013parasite interface. Nevertheless, E\u2010cadherin gene expression was not significantly modulated in this species. On the contrary, no evident changes in the protein distribution were noticed in gilthead sea bream, whereas a significant gene downregulation occurred in advanced infection. The results contribute to the understanding of the different host\u2013parasite interactions in enteromyxoses. Host and parasite cells appear to establish diverse relationships in these species, which could underlie the different pathological picture.<\/jats:p>","DOI":"10.1111\/jfd.13130","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T01:24:41Z","timestamp":1580088281000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of <i>Enteromyxum<\/i> spp. (Myxozoa) infection in the regulation of intestinal E\u2010cadherin: Turbot against gilthead sea bream"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0180-0715","authenticated-orcid":false,"given":"Paolo","family":"Ronza","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda Producci\u00f3n Animal y Ciencias Cl\u00ednicas Veterinarias Universidade de Santiago de Compostela Lugo 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