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However, there are fewer reports about how chlorpyrifos influences the redox balance of immune cells. Herein, the head kidney tissue treated with chlorpyrifos to do transcriptome analysis and TCR \u03b3 was screened out. Subsequently, we established TCR \u03b3 knockdown and overexpression carp head kidney lymphocyte models, respectively, by using RNA interference and pcDNA3.1. Real\u2010time PCR, fluorescent staining, oxidation and antioxidant kit were used to detect the related factors. We found that TCR \u03b3 knockdown significantly increased the mRNA expression of HSP70 and HSP90 and decreased the mRNA expression of SOD and CAT. Meanwhile, TCR \u03b3 knockdown reduced the activities of GSH, GSG\u2010PX, T\u2010AOC, CAT and SOD and increased the content of MDA and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and activities of iNOS. Adverse results were obtained in TCR \u03b3 overexpression group. Additionally, TCR \u03b3 knockdown significantly increased the mRNA expression of IFN\u2010\u03b3, IL\u20101\u03b2, IL\u20108, IL\u201010, Nrf2 and NF\u2010\u03baB, but relieved TCR \u03b3 overexpression, in which the process of inflammation was activated. Our results reported here indicated that chlorpyrifos induces redox imbalance\u2010dependent inflammation in common carp lymphocyte through dysfunction of T\u2010cell receptor \u03b3, and HSPs play potential protective role in entire process.<\/jats:p>","DOI":"10.1111\/jfd.13138","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T06:40:12Z","timestamp":1581489612000},"page":"423-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chlorpyrifos induces redox imbalance\u2010dependent inflammation in common carp lymphocyte through dysfunction of T\u2010cell receptor \u03b3"],"prefix":"10.1111","volume":"43","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Northeast Agricultural University Harbin 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