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The major compounds present in the oleoresin of <jats:italic>C. reticulata<\/jats:italic> were \u03b3\u2010macrocarpene (14.2%), \u03b1\u2010bergamotene (13.6%), \u03b2\u2010selinene (13.4%) and \u03b2\u2010caryophyllene (11.7%). All concentrations of the nanoemulsion and the oleoresin without nanoformulation showed anthelmintic efficacy against monogeneans, and higher concentrations led to more rapid parasite mortality. Structural damages to the tegument of the parasites exposed to <jats:italic>C. reticulata<\/jats:italic> oleoresin were observed with scanning electron microscopy. At two hours of exposure, fish showed 100% tolerance to all nanoemulsion concentrations used in the <jats:italic>in vitro<\/jats:italic> assays, whereas 100% mortality was shown in the fish exposed to the oleoresin without nanoformulation after one hour. The results of this study suggest that nanoemulsions with oleoresin of <jats:italic>C. reticulata<\/jats:italic> have advantages in the control and treatment of monogenean infections in <jats:italic>C. macropomum<\/jats:italic> when compared to the oleoresin without nanoformulation. In addition, since nanoemulsions with the <jats:italic>C. reticulata<\/jats:italic> oleoresin are safe to control monogeneans, the efficacy of these nanoformulations may be assayed in therapeutic baths to treat <jats:italic>C. macropomum<\/jats:italic> infected by monogeneans.<\/jats:p>","DOI":"10.1111\/jfd.13168","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T13:22:07Z","timestamp":1587475327000},"page":"687-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Nanoemulsions with oleoresin of <i>Copaifera reticulata<\/i> (Leguminosae) improve anthelmintic efficacy in the control of monogenean parasites when compared to oleoresin without nanoformulation"],"prefix":"10.1111","volume":"43","author":[{"given":"Dayna Filocre\u00e3o","family":"Malheiros","sequence":"first","affiliation":[{"name":"Postgraduate Program on Tropical Biodiversity (PPGBIO) Federal University of Amap\u00e1 (UNIFAP) Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Icaro Rodrigues","family":"Sarquis","sequence":"additional","affiliation":[{"name":"Group of Biocatalysis and Organic Synthesis Applied Chemistry College Federal University of Amap\u00e1 (UNIFAP) Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irlon Maciel","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Group of Biocatalysis and Organic Synthesis Applied Chemistry College Federal University of Amap\u00e1 (UNIFAP) Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-6642","authenticated-orcid":false,"given":"Patrick Delgado","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Animal Biology Institute of Biology State University of Campinas (UNICAMP) Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Mertins","sequence":"additional","affiliation":[{"name":"Department of Biophysics Paulista School of Medicine Federal University of S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-1846","authenticated-orcid":false,"given":"Marcos","family":"Tavares\u2010Dias","sequence":"additional","affiliation":[{"name":"Postgraduate Program on Tropical Biodiversity (PPGBIO) Federal University of Amap\u00e1 (UNIFAP) Macap\u00e1 Brazil"},{"name":"Embrapa Amap\u00e1 Macap\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"808","volume-title":"Identification of essential oils components by gas chromatography\/mass 402 spectrometry","author":"Adams R. 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