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Infections from human and animal reservoir hosts occur due to the consumption of raw or undercooked fish with <jats:italic>C. sinensis<\/jats:italic> metacercariae. This study aimed to evaluate the prevalence of <jats:italic>C. sinensis<\/jats:italic> metacercariae in fish in South\u2010East Asia via systematic review and meta\u2010analysis. We searched PubMed, ScienceDirect, China National Knowledge Infrastructure, Wanfang and Chongqing VIP databases for studies published between 1976 and 2020 that are related to the prevalence of <jats:italic>C. sinensis<\/jats:italic> metacercariae in fish. Studies were screened with keywords based on inclusion and exclusion criteria. Seventy\u2010one eligible articles were identified, covering three countries: China, Korea and Vietnam. The pooled prevalence of <jats:italic>C. sinensis<\/jats:italic> metacercariae in fish from South\u2010East Asia was 30.5%, with 35.1% in China, 29.7% in Korea and 8.4% in Vietnam. In subgroup analyses of climate, season, water source and publication date, the highest prevalence was identified in the Dwb climate type (43.3%), summer (70.2%), river (34.5%) and pre\u20102001 publications (38.9%), respectively. In comparison, the lowest prevalence was found in the Dfa climate type (14.5%), winter (19.5%), lake (8.0%) and post\u20102001 publications (23.8%). Meta\u2010regression results indicated that country (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009), the published time (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035) and water source subgroups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003) may be the source of heterogeneity. Overall, our study indicates that a high prevalence of <jats:italic>C. sinensis<\/jats:italic> infections occurs in fish in China, Korea and Vietnam, illuminating a significant public health concern in these countries.<\/jats:p>","DOI":"10.1111\/jfd.13245","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T11:55:42Z","timestamp":1599134142000},"page":"1409-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Prevalence of <i>Clonorchis sinensis<\/i> infection in fish in South\u2010East Asia: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China"},{"name":"Branch of Animal Husbandry and 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