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Recently identified cathelicidins derived from alligator and sea snake were found to be more effective in inhibiting microbial growth than other AMPs previously characterized. The ability of these two cathelicidins along with the peptides, cecropin and pleurocidin, to protect channel catfish (<jats:italic>Ictalurus punctatus<\/jats:italic>, Rafinesque) and hybrid catfish (<jats:italic>I. punctatus<\/jats:italic> \u2640\u00a0\u00d7\u00a0blue catfish, <jats:italic>Ictalurus furcatus<\/jats:italic>, Valenciennes <jats:italic>\u2642<\/jats:italic>) against <jats:italic>Edwardsiella ictaluri<\/jats:italic>, one of the most prevalent pathogens affecting commercial catfish industry, was investigated. Cathelicidin\u2010injected fish (50 \u00b5g\u00a0ml<jats:sup>\u22121<\/jats:sup>\u00a0fish<jats:sup>\u22121<\/jats:sup>) that were simultaneously challenged with <jats:italic>E. ictaluri<\/jats:italic> through bath immersion at a concentration of ~1\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup> CFU\/ml had increased survival rates compared with other peptide treatments and the infected control. Bacterial numbers were also reduced in the liver and kidney of channel catfish and hybrid catfish in the cathelicidin treatments 24\u00a0hr post\u2010infection. After 8\u00a0days of challenge, serum was collected to determine immune\u2010related parameters such as bactericidal activity, lysozyme, serum protein, albumin and globulin. These immune\u2010related parameters were significantly elevated in fish injected with the two cathelicidins as compared to other peptide treatments. These results indicate that cathelicidins derived from alligator and sea snake can stimulate immunity and enhance the resistance to <jats:italic>E. ictaluri<\/jats:italic> infection in channel catfish and hybrid catfish.<\/jats:p>","DOI":"10.1111\/jfd.13257","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:30:22Z","timestamp":1600673422000},"page":"1553-1562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cathelicidins enhance protection of channel catfish, <i>Ictalurus punctatus<\/i>, and channel catfish \u2640\u00a0\u00d7\u00a0blue catfish, <i>Ictalurus furcatus<\/i> \u2642 hybrid catfish against <i>Edwarsiella ictaluri<\/i> infection"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-066X","authenticated-orcid":false,"given":"Rhoda Mae C.","family":"Simora","sequence":"first","affiliation":[{"name":"School of Fisheries, Aquaculture and Aquatic Sciences Auburn University  Auburn AL USA"},{"name":"College of Fisheries and Ocean Sciences University of the Philippines Visayas  Miagao Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangjia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Fisheries, Aquaculture and Aquatic Sciences Auburn University  Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermeen Y.","family":"Abass","sequence":"additional","affiliation":[{"name":"School of Fisheries, Aquaculture and Aquatic Sciences Auburn University  Auburn AL USA"},{"name":"Department of Agricultural Botany Faculty of Agriculture Saba\u2010Basha Alexandria University  Alexandria City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery S.","family":"Terhune","sequence":"additional","affiliation":[{"name":"School of Fisheries, Aquaculture and Aquatic Sciences Auburn University  Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex A.","family":"Dunham","sequence":"additional","affiliation":[{"name":"School of Fisheries, Aquaculture and Aquatic Sciences Auburn University  Auburn AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2008.03.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1577\/1548-8667(1993)005<0189:POESOC>2.3.CO;2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-2186-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2017.01.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-09352013000600023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.000425"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.5053-5064.2005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.185-195.2006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170334"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-013-9550-z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.8.2039-2045.2000"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.12008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132504"},{"key":"e_1_2_8_15_1","unstructured":"Dunham R. 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