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The present study aimed to explore the possible protection of <jats:italic>M. rosenbergii<\/jats:italic> against the disease by oral administration of bacterially expressed recombinant capsid proteins of <jats:italic>Mr<\/jats:italic>NV and XSV. Juvenile <jats:italic>M.\u00a0rosenbergii<\/jats:italic> were fed with the feed coated with inactivated bacteria encapsulated expressed recombinant viral proteins either individually or in combination for 7\u00a0days. Challenge studies using WTD causing agents were carried out after 3 (group I), 10 (group II) and 20 (group III) days post\u2010feeding of viral proteins. Recombinant capsid protein of <jats:italic>Mr<\/jats:italic>NV showed better protection when compared to other treatments with relative per cent survival of 62.5% (group I), 57.9% (group II) and 39.5% (group III). Treatment controls of groups I, II and III showed 100%, 95% and 95% mortality, respectively. The study demonstrates that oral administration of recombinant capsid proteins of <jats:italic>Mr<\/jats:italic>NV and XSV provides effective protection against WTD in freshwater prawn.<\/jats:p>","DOI":"10.1111\/jfd.13305","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T09:28:55Z","timestamp":1605778135000},"page":"601-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recombinant viral proteins delivered orally through inactivated bacterial cells induce protection in <i>Macrobrachium rosenbergii<\/i> (de Man) against White Tail Disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4541-5755","authenticated-orcid":false,"given":"Singaiah","family":"NaveenKumar","sequence":"first","affiliation":[{"name":"Fisheries Research Centre Ministry of Environment, Water and Agriculture  Saihat Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-4178","authenticated-orcid":false,"given":"Praveen","family":"Rai","sequence":"additional","affiliation":[{"name":"NITTE (Deemed to be University) Nitte University Centre for Science Education and Research (NUCSER)  Mangaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0690-5129","authenticated-orcid":false,"given":"Indrani","family":"Karunasagar","sequence":"additional","affiliation":[{"name":"NITTE (Deemed to be University) Nitte University Centre for Science Education and Research (NUCSER)  Mangaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iddya","family":"Karunasagar","sequence":"additional","affiliation":[{"name":"Nitte (Deemed to be University), University Enclave, Medical Sciences Complex  Deralakatte, Mangaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"447","volume-title":"Fish biologics: Serodiagnostics and vaccines","author":"Amend D. 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