{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:25:48Z","timestamp":1783650348119,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaesthetics are commonly applied in pharmacokinetic (PK) studies to assure smooth handling of experimental procedures or to promote animal welfare. However, the influence of anaesthetics on the PK of co\u2010administered drug is generally unknown but assumes ignorable. The goal of the study was to investigate the effect of tricaine methanesulfonate (MS\u2010222), 2\u2010phenoxyethanol (2\u2010PE) and eugenol (EUG) on the PK of florfenicol (FF) in Nile tilapia. Twenty\u2010eight fish were repeatedly exposed to 90\u00a0ppm EUG, 300\u00a0ppm MS\u2010222 or 900\u00a0ppm 2\u2010PE before FF oral administration (15\u00a0mg\/kg) and each successive blood sampling. The serum concentration\u2013time profiles were analysed by a 2\u2010compartmental model, and the generated parameters in the control (without anaesthetic) and anaesthetic groups were statistically compared. The results demonstrated that the serum concentrations of each anaesthetic were similar at every FF sampling times (70\u00a0\u03bcg\/ml for MS\u2010222; 277\u00a0\u03bcg\/ml for 2\u2010PE; and 61\u00a0\u03bcg\/ml for EUG). In comparison with the control group, the repeated use of MS\u2010222 did not result in a statistical difference in most of the PK parameters. In contrast, the elimination half\u2010lives of the 2\u2010PE and EUG groups were significantly longer whereas the absorption and distribution half\u2010lives of the 2\u2010PE group were significantly shorter than the control, resulting in altered optimal dosages in the simulation modelling. Whether or not the numbers and extent of PK parameters change mitigate subsequent estimations of other PK\u2010derived secondary values such as dosing regimen and withdrawal time remains to be elucidated, but the auxiliary use of anaesthetics in PK studies should not assume uninfluential.<\/jats:p>","DOI":"10.1111\/jfd.13480","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T14:46:14Z","timestamp":1624286774000},"page":"1579-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differential effects of aquatic anaesthetics on the pharmacokinetics of antibiotics: Examples using florfenicol in Nile tilapia (<i>Oreochromis niloticus<\/i>)"],"prefix":"10.1111","volume":"44","author":[{"given":"T","family":"Rairat","sequence":"first","affiliation":[{"name":"Department of Fishery Biology Faculty of Fisheries Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Veterinary Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u2010K","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u2010Y","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Veterinary Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Chuchird","sequence":"additional","affiliation":[{"name":"Department of Fishery Biology Faculty of Fisheries Kasetsart University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-2552","authenticated-orcid":false,"given":"C\u2010C","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Veterinary Medicine National Chung Hsing University Taichung Taiwan"},{"name":"Department and Graduate Institute of Pharmacology National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Anesthetics in Aquaculture (SRAC Publication, Vol. No. 3900)","author":"Coyle S. 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