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Contrary to previous studies with certain host\u2013parasite pairs, this research compares the inhibitory capacities in three tapeworm species of the same genus <jats:italic>Proteocephalus<\/jats:italic> from four different fishes (<jats:italic>P<\/jats:italic>. <jats:italic>torulosus<\/jats:italic> from dace and zope, <jats:italic>P<\/jats:italic>. <jats:italic>sagittus<\/jats:italic> from stone loach and <jats:italic>P<\/jats:italic>. <jats:italic>cernuae<\/jats:italic> from ruffe). The tapeworm extracts studied significantly reduced the activity of commercial trypsin (although to a lesser degree than the synthetic inhibitor of serine proteinases PMSF), displaying clear inter\u2010specific variation in worms\u2019 inhibitory ability. We also measured the proteolytic activity of the host intestinal mucosa exposed to tapeworm extracts which served as inhibitors. Based on per cent inhibition values, all tapeworm extracts significantly suppressed the mucosal proteolytic activity, with marked differences between certain host\u2013parasite pairs. SDS\u2010PAGE electrophoresis of the incubation media and extracts detected in each tapeworm species 20\u201336 protein bands with apparent molecular weights from 10\u201312 to 312.5\u00a0kDa, mostly below 50\u00a0kDa. The incubation medium and extract of each parasite shared one to six bands ranging from 12 to 35\u00a0kDa, depending on its species, with only four bands common for two or more species. The band profiles suggest that in various <jats:italic>Proteocephalus<\/jats:italic> species inhibitory capacities against host proteinases can be ensured by different proteins.<\/jats:p>","DOI":"10.1111\/jfd.13624","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T07:52:26Z","timestamp":1650441146000},"page":"1011-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surviving in the fish gut: Comparative inhibitory capacities against the host proteinases in cestodes of the genus <i>Proteocephalus<\/i>"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-9763","authenticated-orcid":false,"given":"Galina I.","family":"Izvekova","sequence":"first","affiliation":[{"name":"Papanin Institute for Biology of Inland Waters Russian Academy of Sciences  Borok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-1785","authenticated-orcid":false,"given":"Tatyana V.","family":"Frolova","sequence":"additional","affiliation":[{"name":"Papanin Institute for Biology of Inland Waters Russian Academy of Sciences  Borok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7623-9822","authenticated-orcid":false,"given":"Evgeny I.","family":"Izvekov","sequence":"additional","affiliation":[{"name":"Papanin Institute for Biology of Inland Waters Russian Academy of Sciences  Borok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-3311","authenticated-orcid":false,"given":"Alexander E.","family":"Zhokhov","sequence":"additional","affiliation":[{"name":"Papanin Institute for Biology of Inland Waters Russian Academy of Sciences  Borok Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0965\u20101748(01)00087\u2010x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12562\u2010020\u201001422\u20104"},{"key":"e_1_2_9_4_1","first-page":"514","article-title":"Morphological variability of the cestode (Proteocephalus longicollis), a parasite of salmonoidei from local populations of the smelt (Osmerus eperlanus)","volume":"89","author":"Anikieva L. 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