{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:06:43Z","timestamp":1787069203306,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000193","name":"International Development Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rapid growth and intensification of aquaculture industries have led to an increased use of antibiotics. Consequently, growing concerns have mounted over the environmental contamination of these drugs from medicated feeds and the risk that this poses for antimicrobial resistance. To circumvent environmental leaching, farmers topcoat medicated feeds with oil; however, this only partially addresses the issue. This study investigated the potential of food\u2010grade pregelatinized corn starch (PGS) as a second top\u2010coating agent to reduce oxytetracycline (OTC) leaching from the hand\u2010mixed medicated feed. We immersed top\u2010coated medicated feeds for different periods of time and measured the concentration of OTC in the water to determine leaching. We found a significantly lower level of OTC in water samples collected from the PGS\u2010coated medicated feed compared to the non\u2010PGS\u2010coated medicated feed, with concentrations of OTC approximately 4 and 2.6 times the latter after 5\u2009min and 2\u2009h of water immersion, respectively. We also fed PGS\u2010coated antibiotic feed to jade perch to determine if fish accepted the top\u2010coating and whether they absorbed the OTC. Results from a feeding trial suggested no difference in palatability between PGS and non\u2010PGS\u2010coated medicated feed. We also found that muscle tissue from fish fed with the aforementioned diets had similar levels of OTC concentrations, suggesting that PGS coating does not alter the gastrointestinal absorption of this medication. From our experiment, we conclude that PGS is potentially a new top\u2010coating agent to reduce leaching in hand\u2010mixed OTC medicated feed.<\/jats:p>","DOI":"10.1111\/jfd.13838","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T06:46:47Z","timestamp":1689922007000},"page":"1183-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of oxytetracycline leaching from pregelatinized starch\u2010coated medicated fish feed"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-1881","authenticated-orcid":false,"given":"A. R.","family":"Marques","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-5680","authenticated-orcid":false,"given":"K. Y.","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. B.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Chemical Testing Services, Department of Chemistry Hong Kong Baptist University  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"St\u2010Hilaire","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong  Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Alibaba. (2023).Factory price food grade Pre\u2010gelatinized Starch pregelatinized starch.https:\/\/www.alibaba.com\/product\u2010detail\/Factory\u2010price\u2010food\u2010grade\u2010Pre\u2010gelatinized_1600262422137.html#:~:text=%240.80%20\u2010%20%2410.00%2F Kilogram%20%7C1%20Kilogram%2FKilograms%28Min.%20Order%29"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2008.05.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.08.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2020.115699"},{"key":"e_1_2_10_7_1","unstructured":"Bortone E.(2006).Vacuum process supports high oil content in feed coatings.Global Aquaculture Advocate.https:\/\/www.globalseafood.org\/advocate\/vacuum\u2010process\u2010supports\u2010high\u2010oil\u2010content\u2010in\u2010feed\u2010coatings\/"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaeng.2020.102127"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.88273"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2016.1267875"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.170"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.07.061"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2023.739481"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.795348"},{"key":"e_1_2_10_15_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.19080\/NFSIJ.2017.03.555618"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102109.1999.00410.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2004.05.009"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11160\u2010005\u20107850\u20108"},{"key":"e_1_2_10_20_1","volume-title":"The use of veterinary drugs and vaccines in Mediterranean aquaculture","author":"Rogers C.","year":"2009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2017.09.022"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201078849\u20103"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102095.2011.00924.x"},{"key":"e_1_2_10_24_1","volume-title":"Method 1694: Pharmaceuticals and personal care products in water, soil, sediment, and biosolids by HPLC\/MS\/MS","author":"USEPA","year":"2007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1300\/J028v04n01_03"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1577\/H03\u2010065.1"},{"key":"e_1_2_10_28_1","first-page":"127","volume-title":"Improving biosecurity through prudent and responsible use of veterinary medicines in aquatic food production","author":"Zarza C.","year":"2012"}],"container-title":["Journal of Fish Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfd.13838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:56:01Z","timestamp":1697072161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfd.13838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/jfd.13838"],"URL":"https:\/\/doi.org\/10.1111\/jfd.13838","archive":["Portico"],"relation":{},"ISSN":["0140-7775","1365-2761"],"issn-type":[{"value":"0140-7775","type":"print"},{"value":"1365-2761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]},"assertion":[{"value":"2023-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}