{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:50:06Z","timestamp":1787064606076,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study explored the bactericidal role of the epidermal mucus (EM) of five freshwater Cyprinid fish species namely\n                    <jats:italic>Ctenopharyngodon idella<\/jats:italic>\n                    ,\n                    <jats:italic>Labeo rohita<\/jats:italic>\n                    ,\n                    <jats:italic>Catla catla<\/jats:italic>\n                    ,\n                    <jats:italic>Hypophthalmichthys molitrix<\/jats:italic>\n                    , and\n                    <jats:italic>Cirrhinus mrigala<\/jats:italic>\n                    after treatment with\n                    <jats:italic>Aeromonas hydrophila<\/jats:italic>\n                    . Extracts of EM (crude and acidic) of each species showed bactericidal activity against various Gram \u2212ve (\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Aeromonas hydrophila<\/jats:italic>\n                    ,\n                    <jats:italic>Edwardsiella tarda<\/jats:italic>\n                    ,\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumonia<\/jats:italic>\n                    ,\n                    <jats:italic>Serratia marcescens<\/jats:italic>\n                    , and\n                    <jats:italic>Enterobacter cloacae<\/jats:italic>\n                    ) and Gram +ve (\n                    <jats:italic>Bacillus wiedmannii<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) bacteria compared with standard antibiotics (Fosfomycin). The zone of inhibition (ZOI) was measured in millimetres against antibiotics (Fosfomycin). Variations in bactericidal activity of EM were observed against bacteria from the same and different fish species. The acidic extract was more effective than the crude extract and showed significantly higher ZOI values against various bacteria and Fosfomycin antibiotics. This result shows that fish EM may perform an important role in fish defence against bacteria. Therefore, this study may hint towards the substitution of synthetic antibiotics with fish EM that may be used as a novel \u2018bactericidal\u2019 in aquaculture as well as in humans against bacterial infections.\n                  <\/jats:p>","DOI":"10.1111\/jfd.13841","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T02:49:33Z","timestamp":1690512573000},"page":"1225-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bactericidal role of epidermal mucus of freshwater fish treated with\n                    <i>Aeromonas hydrophila<\/i>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-7243","authenticated-orcid":false,"given":"Shandana","family":"Ali","sequence":"first","affiliation":[{"name":"Laboratory of Fisheries and Aquaculture, Department of Zoology Kohat University of Science and Technology Kohat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-1043","authenticated-orcid":false,"given":"Syed Ata Ur Rahman","family":"Shah","sequence":"additional","affiliation":[{"name":"Laboratory of Fisheries and Aquaculture, Department of Zoology Kohat University of Science and Technology Kohat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Rauf","sequence":"additional","affiliation":[{"name":"Laboratory of Fisheries and Aquaculture, Department of Zoology Kohat University of Science and Technology Kohat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maizom","family":"Hassan","sequence":"additional","affiliation":[{"name":"Institute of System Biology (INBIOSIS) Universiti Kebangsaan Malaysia (UKM) Bangi Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waheed","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Microbiology Kohat University of Science and Technology Kohat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farman Ullah","family":"Dawar","sequence":"additional","affiliation":[{"name":"Laboratory of Fisheries and Aquaculture, Department of Zoology Kohat University of Science and Technology Kohat Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2023.102731"},{"key":"e_1_2_8_3_1","first-page":"164","article-title":"Effect of crude and partially purified epidermal mucus proteins of marine catfish Tachysurus dussumieri on human cancer cell line","volume":"1","author":"Arulvasu C.","year":"2012","journal-title":"Journal of Academia and Industrial Research"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4_ts.493"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aaf.2021.08.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2022.2137145"},{"key":"e_1_2_8_7_1","first-page":"283","volume-title":"Handbook of plant ecophysiology techniques","author":"Bonjoch N. 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