{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:46:41Z","timestamp":1777420001569,"version":"3.51.4"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016931","name":"Havforskningsinstituttet","doi-asserted-by":"publisher","award":["15357"],"award-info":[{"award-number":["15357"]}],"id":[{"id":"10.13039\/100016931","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lufenuron is a benzoylurea insecticide currently in use to combat sea lice infestation in salmon aquaculture in Chile. With pending approval in Norway, the aim of this work was to study the uptake and toxicity of lufenuron in liver tissue of Atlantic salmon. Juvenile salmon weighing 40\u2009g were given a standard 7\u2010day oral dose, and bioaccumulation and transcriptional responses in the liver were examined 1\u2009day after the end\u2010of\u2010treatment (day 8) and after 1\u2009week of elimination (day 14). Bioaccumulation levels of lufenuron were 29\u2009\u00b1\u20093\u2009mg\/kg at day 8 and 14\u2009\u00b1\u20091\u2009mg\/kg at day 14, indicating relatively rapid clearance. However, residues of lufenuron were still present in the liver after 513\u2009days of depuration. The exposure gave a transient inhibition of transcription in the liver at day 8 (2437 significant DEGs, <jats:italic>p<\/jats:italic>\u2010adj\u2009&lt;\u2009.05), followed by a weaker compensatory response at day 14 (169 significant DEGs). Pathways associated with RNA metabolism such as the sumoylation pathway were most strongly affected at day 8, while the apelin pathway was most profoundly affected at day 14. In conclusion, this study shows that lufenuron easily bioaccumulates and that a standard 7\u2010day oral dose induces a transient inhibition of transcription in liver of salmon.<\/jats:p>","DOI":"10.1111\/jfd.13880","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T06:45:05Z","timestamp":1699339505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lufenuron treatment temporarily represses gene expression and affects the <scp>SUMO<\/scp> pathway in liver of Atlantic salmon"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5641-9420","authenticated-orcid":false,"given":"P\u00e5l A.","family":"Olsvik","sequence":"first","affiliation":[{"name":"Faculty of Biosciences and Aquaculture Nord University  Bod\u00f8 Norway"},{"name":"Institute of Marine Research  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine E.","family":"Brokke","sequence":"additional","affiliation":[{"name":"Institute of Marine Research  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole B.","family":"Samuelsen","sequence":"additional","affiliation":[{"name":"Institute of Marine Research  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Hannisdal","sequence":"additional","affiliation":[{"name":"Institute of Marine Research  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.12.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/691981"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010465"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106245"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.34"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76638-6"},{"key":"e_1_2_10_8_1","unstructured":"Bernhard A. Azad A. M. &Hannisdal R.(2022).Monitoring program for pharmaceuticals illegal substances and contaminants in farmed fish\u2010annual report for 2020.Rapport fra Havforskningen 2022\u20132026."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13657305.2020.1737272"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503709102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0315"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12815"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15319"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.08.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113550"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3342"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2183-z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/eesa.1996.0065"},{"key":"e_1_2_10_19_1","unstructured":"EFSA. (2008).Conclusion regarding the peer review of the pesticide risk assessment of the active substance lufenuron.https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/rn\u2010189"},{"key":"e_1_2_10_20_1","unstructured":"EMA(2015).https:\/\/www.ema.europa.eu\/en\/documents\/mrl\u2010report\/lufenuron\u2010fin\u2010fish\u2010european\u2010public\u2010maximum\u2010residue\u2010limit\u2010assessment\u2010report\u2010epmar\u2010cvmp_en.pdf"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13008-015-0010-1"},{"key":"e_1_2_10_22_1","unstructured":"EU(2010\/37).https:\/\/eur\u2010lex.europa.eu\/legal\u2010content\/EN\/TXT\/PDF\/?uri=CELEX:02010R0037\u201020220509&qid=1667391131235&from=EN"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2293"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2019.734634"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.07.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.25"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-04655-8"},{"key":"e_1_2_10_28_1","unstructured":"Hobbs G.(2014).The metabolism excretion and residue depletion of [14C]\u2010Lufenuron in the Atlantic salmon (Salmo salarL.). Charles River: 34776 p.148. GLP Compliant. Unpublished Elanco Animal Health Report. Cited in: McHenery J. G. (2016). Lufenuron for salmonids. Environmental assessment in support of an import tolerance request.https:\/\/www.fda.gov\/media\/100121\/download"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.312"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113289"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401843"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111297"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/es5005329"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.06.017"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28937"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00221"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2920"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jepm.2012.12.010"},{"key":"e_1_2_10_41_1","unstructured":"McHenery J. G.(2016).Lufenuron for salmonids \u2013 Environmental assessment in support of an import tolerance request.Elanco Animal Health report(pp. 1\u201325)."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-019-00747-x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052760"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.27.20130030"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3739"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2017.09.005"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2015.07.008"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao02613"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00460-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.02.007"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.115390"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00287"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0457-2"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.11.082"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.09.007"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.08.007"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112098"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2021.103597"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.07.033"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b00749"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12061"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)00001-8"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2015.04.016"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2021.105193"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-55"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.11.007"},{"issue":"4","key":"e_1_2_10_67_1","first-page":"353","article-title":"Sumoylation modulates oxidative stress relevant to the viability and functionality of pancreatic beta cells","volume":"6","author":"Yang P.","year":"2014","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01394.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20309"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.05.006"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/imb.12829"}],"container-title":["Journal of Fish Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfd.13880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T08:53:05Z","timestamp":1705740785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfd.13880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,6]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jfd.13880"],"URL":"https:\/\/doi.org\/10.1111\/jfd.13880","archive":["Portico"],"relation":{},"ISSN":["0140-7775","1365-2761"],"issn-type":[{"value":"0140-7775","type":"print"},{"value":"1365-2761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,6]]},"assertion":[{"value":"2023-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13880"}}