{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:36Z","timestamp":1787015556516,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A cohort of Chinook salmon juveniles was vaccinated, with an autogenous bivalent vaccine against New Zealand RLOs (NZ\u2010RLO1) and\n                    <jats:italic>Tenacibaculum maritimum.<\/jats:italic>\n                    A proportion of the cohort was not vaccinated to act as controls. At smoltification, the fish were challenged with NZ\u2010RLO1, NZ\u2010RLO2, or\n                    <jats:italic>T. maritimum<\/jats:italic>\n                    . We found that challenge with\n                    <jats:italic>T. maritimum<\/jats:italic>\n                    by immersion in (7.5\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    \u2009cfu\/mL of water) did not yield any pathology. Challenge with RLOs produced clinical signs that were more or less severe depending on the challenge route, dose or vaccination status. Survival was significantly higher for vaccinated fish within the groups challenged with NZ\u2010RLO1 by intraperitoneal injection with a relative percent survival (RPS) of 48.84%. Survival was not significantly different between vaccinated and non\u2010vaccinated fish for groups challenged with NZ\u2010RLO2 by intraperitoneal injection or by NZ\u2010RLO1 by immersion. Yet, anecdotally the clinical disease presentation (manifesting as haemorrhagic, ulcerative skin lesions) was more severe for the non\u2010vaccinated fish. This study demonstrates that autogenous vaccine against NZ\u2010RLO is protective against severe disease and death by NZ\u2010RLO1 challenge which warrants implementation and further evaluation under field conditions. Yet, this study also highlights the importance of the route of administration and dose when evaluating pathogenicity and vaccine efficacy.\n                  <\/jats:p>","DOI":"10.1111\/jfd.13883","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T04:45:12Z","timestamp":1700196312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New Zealand rickettsia\u2010like organism and\n                    <i>Tenacibaculum maritimum<\/i>\n                    vaccine efficacy study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-0940","authenticated-orcid":false,"given":"D.","family":"Jaramillo","sequence":"first","affiliation":[{"name":"Biosecurity New Zealand Ministry for Primary Industries  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3410-9998","authenticated-orcid":false,"given":"B. P.","family":"Busby","sequence":"additional","affiliation":[{"name":"Animal Health Laboratory Ministry for Primary Industries  Upper Hutt New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bestbier","sequence":"additional","affiliation":[{"name":"Animal Health Laboratory Ministry for Primary Industries  Upper Hutt New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Animal Health Laboratory Ministry for Primary Industries  Upper Hutt New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Waddington","sequence":"additional","affiliation":[{"name":"New Zealand King Salmon Ltd  Picton New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.78.1.25\u201032.1959"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao071255"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3147\/jsfp.22.105"},{"key":"e_1_2_10_5_1","unstructured":"Brosnahan C.(2020).Diagnostic investigation into summer mortality events of farmed Chinook salmon (Oncorhynchus tshawytscha) in New Zealand: A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University Manawat\u016b New Zealand. Massey University."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00288330.2016.1242081"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao03364"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12909"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1577\/1548\u20108667(1995)007<0318:IACOMF>2.3.CO;2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao064037"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"95","article-title":"Development of a TaqMan quantitative PCR assay for the identification of Piscirickettsia salmonis","volume":"23","author":"Corbeil S.","year":"2003","journal-title":"Bulletin of the European Association of Fish Pathologists"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11070993"},{"key":"e_1_2_10_13_1","unstructured":"Fischer J. &Appleby J.(2017).MPI Technical Paper No. 2017\/39 Intelligence Report NZ\u2010RLO& T. maritimum 2015 response. Wellington: Publications Logistics Officer."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206951"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12818"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102761.2003.00460.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00503\u201016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.734968"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264\u2010410X(00)00524\u20107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1068000"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1244483"},{"key":"e_1_2_10_22_1","unstructured":"MPI. (2019).SECTION 131 \u2010 Controlled area movement controls and procedures in respect of: New zealand rickettsia\u2010like organism (NZ Rickettsiaceae sp.). M. f. P. Industries. Wellington Biosecurity New Zealand.https:\/\/www.mpi.govt.nz\/dmsdocument\/12007\u2010Controlled\u2010area\u2010notice\u2010in\u2010respect\u2010of\u2010NZ\u2010Rickettsia\u2010like\u2010Organism\u2010NZ\u2010Rikettsiaceae\u2010sp"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016142"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10111439"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12211"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao061053"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2008.11.012"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.03.027"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.586387"}],"container-title":["Journal of Fish Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jfd.13883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T03:52:30Z","timestamp":1705722750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jfd.13883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/jfd.13883"],"URL":"https:\/\/doi.org\/10.1111\/jfd.13883","archive":["Portico"],"relation":{},"ISSN":["0140-7775","1365-2761"],"issn-type":[{"value":"0140-7775","type":"print"},{"value":"1365-2761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,17]]},"assertion":[{"value":"2023-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13883"}}