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High visual acuity is key for health and survival of farmed, cultured, and wild fish. Cleaner fish technology to control parasite infestation has become important in marine aquaculture and highlights the importance of visual acuity in the efficacy of cleaner fish species. New clinical diagnostic approaches towards understanding and optimising fish visual health could benefit both aquacultured and wild fish populations. Opportunities for developing and using advanced non\u2010invasive clinical assessment and diagnosis of ocular health in wild, cultured, and experimental fish are key to more rapidly realising how threats to eye health in these animals might be better understood and mitigated. Ophthalmoscopy can rapidly and non\u2010invasively image anatomical aspects of retinal and anterior ocular tissues and has been used in mammalian biomedicine since the turn of the 20th century. More now than ever, labour\u2010intensive post\u2010mortem approaches for ocular analysis such as histology are increasingly being replaced or supplemented by application of various forms of optical coherence tomography (OCT) imaging of ocular tissues in mammalian biomedicine. Advances and availability of other methodological approaches such as three\u2010dimensional printing and computer science make instrument customisation affordable and adaptable. This review article will outline how ophthalmoscopy, OCT, and other methodologies are being applied towards understanding ocular health in teleost fish species and will describe some of the future opportunities that technological advances might afford in advancing ocular imaging in fish health and disease in general.<\/jats:p>","DOI":"10.1111\/jfd.14072","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T11:34:17Z","timestamp":1734348857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Application of Non\u2010Invasive Methodological Approaches in Biomedical Sciences Towards Better Understanding of Marine Teleost Ocular Health and Disease"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-1516","authenticated-orcid":false,"given":"Robert L.","family":"Gendron","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca R.","family":"Kwabiah","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine Memorial University of Newfoundland  St. John's Newfoundland Canada"},{"name":"Marine Microbial Pathogenesis and Vaccinology Lab Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Paradis","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Tucker","sequence":"additional","affiliation":[{"name":"The Dr. Joe Brown Aquatic Research Building, Department of Ocean Sciences Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Boyce","sequence":"additional","affiliation":[{"name":"The Dr. Joe Brown Aquatic Research Building, Department of Ocean Sciences Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-3147","authenticated-orcid":false,"given":"Javier","family":"Santander","sequence":"additional","affiliation":[{"name":"Marine Microbial Pathogenesis and Vaccinology Lab Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2022.2071743"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.13892"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2024.108253"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201016638\u20100_3"},{"key":"e_1_2_11_6_1","first-page":"492","article-title":"Novel Segmentation Algorithm for High\u2010Throughput Analysis of Spectral Domain\u2010Optical Coherence Tomography Imaging of Teleost Retinas","volume":"28","author":"Barter K. 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