{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:42:35Z","timestamp":1782769355144,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>An outbreak of <jats:italic>Cryptocaryon irritans<\/jats:italic> (<jats:italic>Ci<\/jats:italic>) occurred during the quarantine of marine teleost fish at a large aquarium facility, leading to 457 mortalities across 16 species. This study investigates the outbreak through a retrospective analysis of clinical and pathological findings, emphasising the role of detailed pathology in outbreak characterisation. Lesion diversity, host\u2010specific susceptibility and mortality rates were examined alongside molecular diagnostics to confirm <jats:italic>Ci<\/jats:italic> presence. Key findings include significant differences in susceptibility and pathological presentations among fish families, with <jats:italic>Chaetodontidae<\/jats:italic> and <jats:italic>Acanthuridae<\/jats:italic> exhibiting severe gill and skin pathology, whereas <jats:italic>Labridae<\/jats:italic> and <jats:italic>Scaridae<\/jats:italic> showed enhanced parasite clearance associated with mucus production. A variety of treatment modalities were used, including formalin bath, Leteux\u2013Meyer mixture and chloroquine, with variable treatment responses and species\u2010specific drug sensitivities. Molecular analysis confirmed <jats:italic>Ci<\/jats:italic> with high sequence identity to isolates from the Red Sea and East Asia but highlighted primer limitations for frozen samples. This study outlines the challenges of managing a <jats:italic>Ci<\/jats:italic> outbreak in quarantine under unprecedented environmental conditions, underscores the importance of species\u2010specific management strategies and provides detailed insights into host\u2013pathogen interactions and treatment responses.<\/jats:p>","DOI":"10.1111\/jfd.14084","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T11:05:44Z","timestamp":1738667144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Outbreak of <i>Cryptocaryon irritans<\/i> in Aquarium Quarantine\u2014New Variations of an Old Theme"],"prefix":"10.1111","volume":"48","author":[{"given":"Daniela","family":"Denk","sequence":"first","affiliation":[{"name":"SeaWorld Yas Island Abu Dhabi  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Boylan","sequence":"additional","affiliation":[{"name":"SeaWorld Yas Island Abu Dhabi  Abu Dhabi UAE"},{"name":"Georgia Sea Turtle Center  Jekyll Island Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank T.","family":"Just","sequence":"additional","affiliation":[{"name":"Department for Pathology, Parasitology and Bee Diseases Bavarian Health and Food Safety Authority  Oberschleissheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Sommer","sequence":"additional","affiliation":[{"name":"SeaWorld Yas Island Abu Dhabi  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Elsburgh O.","family":"Clarke","sequence":"additional","affiliation":[{"name":"SeaWorld Yas Island Abu Dhabi  Abu Dhabi UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Anon. n.d.\u201cArtifacts in Histopathology: An Experimental Study.\u201dhttps:\/\/cdn.technologynetworks.com\/ep\/pdfs\/artifacts\u2010in\u2010histopathology\u2010an\u2010experimental\u2010study.pdf."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/d14121015"},{"key":"e_1_2_9_4_1","volume-title":"Cryptocaryon irritans Brown, 1951 (Ciliophora): transmission and immune response in the mullet Chelon labrosus (Risso, 1826)","author":"Burgess P. 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