{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:37:44Z","timestamp":1787765864228,"version":"build-2784847793"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite recent genomic studies and increased molecular data, epitheliocystis remains an enigmatic fish disease with no experimental in\u00a0vitro or in\u00a0vivo models to aid the advancement of research. In this study, we revert to a classical microscopical approach and screen with the electron microscope the epitheliocystis lesions caused by a\n                    <jats:italic>Ca<\/jats:italic>\n                    . Parilichlamydia sp., infecting mucus cells in Greater amberjack. We report distinct morphological features of this bacterial family, characterised by Intermediate Bodies that closely resemble those of previously described\n                    <jats:italic>Candidatus similchlamydia<\/jats:italic>\n                    , and Elementary Bodies that exhibit morphological similarities to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    <\/jats:styled-content>\n                    . We describe the characteristics of a novel Chlamydial Inclusion Membrane (IM) type, with abundant interdigitations, possibly shaped by fusion of the IM with cytoplasmic vesicles, and moreover discuss the presence of multivesicular bodies in the infected cell. Our observation of immune cells in the infected areas indicates an interaction of macrophages with infected cells, a role for granular cells as pathogens reservoirs and an active phagoptosis process in the nearby areas, overall shedding light on cellular immune processes characterising these infections in fish hosts.\n                  <\/jats:p>","DOI":"10.1111\/jfd.14146","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T01:00:38Z","timestamp":1747875638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrastructural Insights Into a\n                    <i>Candidatus<\/i>\n                    Parilichlamydia sp. Infection of Gill Goblet Cells in Greater Amberjack"],"prefix":"10.1111","volume":"48","author":[{"given":"Maria Chiara","family":"Cascarano","sequence":"first","affiliation":[{"name":"University of Crete  Heraklion Crete Greece"},{"name":"Institute of Marine Biology, Biotechnology and Aquaculture Hellenic Centre for Marine Research  Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papadogiorgaki","family":"Sevasti","sequence":"additional","affiliation":[{"name":"University of Crete  Heraklion Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-5068","authenticated-orcid":false,"given":"Pantelis","family":"Katharios","sequence":"additional","affiliation":[{"name":"Institute of Marine Biology, Biotechnology and Aquaculture Hellenic Centre for Marine Research  Heraklion Crete 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