{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:19:07Z","timestamp":1791839947663,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21221163"],"award-info":[{"award-number":["21221163"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1241544"],"award-info":[{"award-number":["1241544"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Piscirickettsia salmonis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , the causal agent of salmonid rickettsial septicemia (SRS), is the main pathogen affecting farmed salmonids in Chile. Outbreaks of SRS lead to substantial economic losses for producers. Many determinants related to SRS outcomes are still poorly understood. Here, we conducted a retrospective cohort study from 2014 to 2021 to investigate the epidemiology of SRS at the farm level in southern Chile, employing historical monitoring data. Using time series analysis of weekly SRS mortality risk and sea lice (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Caligus rogercresseyi<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) infestation levels, we found that SRS mortality risk had a strong seasonal component, with mortalities being significantly higher in the warmer seasons. While\n                    <jats:italic>Caligus<\/jats:italic>\n                    infestation levels have increased significantly over the years, SRS mortality risk has remained constant. Using mixed effects regression models, we identified that a key predictor for both increased weekly SRS mortality risk and higher hazard of reporting the first SRS outbreak of a production cycle was the level of female egg\u2010laying sea lice. We hypothesise that the interaction between sea lice,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. salmonis<\/jats:italic>\n                    <\/jats:styled-content>\n                    and rising water temperatures may produce synergistic stress on salmon that accelerates disease progression and prompts overuse of antimicrobials. This calls for an urgent integrated pest management approach in aquaculture practice.\n                  <\/jats:p>","DOI":"10.1111\/jfd.70097","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:37:36Z","timestamp":1765280256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiology of Salmonid Rickettsial Septicemia (\n                    <scp>SRS<\/scp>\n                    ) in Farmed Salmon: The Role of Sea Lice Infestations in Mortality Risk"],"prefix":"10.1111","volume":"49","author":[{"given":"Benjam\u00edn","family":"Diethelm\u2010Varela","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolhole","family":"Atero","sequence":"additional","affiliation":[{"name":"Escuela de Salud P\u00fablica Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"C\u00f3rdova\u2010B\u00fchrle","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Extensi\u00f3n y Vinculaci\u00f3n con el Medio, Facultad de Ciencias Veterinarias y Pecuarias (FAVET) Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico L.","family":"Rezende","sequence":"additional","affiliation":[{"name":"Center of Applied Ecology and Sustainability (CAPES), Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Catolica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gelcich","sequence":"additional","affiliation":[{"name":"Instituto Milenio en Socioecologia Costera, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Servicio Nacional de Pesca y Acuicultura, Ministerio de Econom\u00eda, Gobierno de Chile  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Navarro","sequence":"additional","affiliation":[{"name":"Servicio Nacional de Pesca y Acuicultura, Ministerio de Econom\u00eda, Gobierno de Chile  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1228-5392","authenticated-orcid":false,"given":"Fernando O.","family":"Mardones","sequence":"additional","affiliation":[{"name":"Escuela de Medicina Veterinaria, Facultad de Agronom\u00eda e Ingenier\u00eda Forestal, Facultad de Ciencias Biol\u00f3gicas y Facultad de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Division of Global Agriculture and Food Systems, Royal (Dick) School of Veterinary Studies The University of Edinburgh  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2019.104771"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/raq.12702"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3354\/aei00368"},{"issue":"3","key":"e_1_2_12_5_1","first-page":"3","article-title":"Coho Salmon Syndrome in Chile","volume":"17","author":"Bravo S.","year":"1989","journal-title":"FHS\/AFS Newsletter"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","unstructured":"Brooks M. 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