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Two experiments were conducted at three different temperatures: a 6\u2010week freshwater experiment with fish weighing 50\u2013100\u2009g, undergoing up to four blood withdrawals, and a 4\u2010week seawater experiment with fish weighing 300\u2013450\u2009g, undergoing up to three blood withdrawals. Observed clinical signs included dark pigmentation of the skin and vascular disturbances posterior to the puncture site. Histological evaluations revealed injuries to the vasculature, vertebral column, nervous tissue and skeletal muscle. At 12\u00b0C and 15\u00b0C, fish displayed strong capacity for tissue regeneration and haematological recovery, but also an elevated risk of acute mortality. At 5\u00b0C, acute mortality was minimal, but recovery time was approximately twice as long compared with higher temperatures. Mortality rates and clinical findings decreased with increasing fish weight. 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