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To investigate the intestinal microbial changes associated with bacterial enteritis in captive populations, we integrated bacterial isolation with metagenomic sequencing to characterize both healthy and maladjusted gut microbiomes. Healthy sturgeons exhibited a stable microbiota dominated by the beneficial\n                    <jats:italic>Cetobacterium<\/jats:italic>\n                    . In contrast, enteritis was consistently associated with severe dysbiosis, characterized by the depletion of these commensals and the massive expansion of opportunistic pathogens, notably\n                    <jats:italic>Aeromonas<\/jats:italic>\n                    and\n                    <jats:italic>Citrobacter<\/jats:italic>\n                    . Culture\u2010based analyses identified\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. veronii<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. freundii<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Plesiomonas shigelloides<\/jats:italic>\n                    <\/jats:styled-content>\n                    as the dominant cultivable bacteria from diseased individuals; these isolates harboured diverse virulence traits and were multidrug\u2010resistant. Crucially, both sturgeon species showed highly similar microbial responses and pathogenic profiles during enteritis. These findings indicate that sturgeon enteritis is closely correlated with a dysbiosis\u2010driven syndrome. Establishing the healthy baseline provides a critical theoretical foundation for screening autochthonous probiotics and developing targeted pathogen control strategies. Furthermore, the striking cross\u2010species commonality validates the Yangtze sturgeon as a viable surrogate model for advancing disease management and conservation in the difficult\u2010to\u2010breed Chinese sturgeon.\n                  <\/jats:p>","DOI":"10.1111\/jfd.70218","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:44:22Z","timestamp":1780713862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gut Microbiota Dysbiosis Drives Lethal Bacterial Enteritis in Sturgeons: Insights From Ex\u00a0Vivo Cultivation and Metagenomic Investigations"],"prefix":"10.1111","volume":"49","author":[{"given":"Dike","family":"Peng","sequence":"first","affiliation":[{"name":"National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University  Shanghai China"},{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai 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