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In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation\u2010mediated infection assay and histological and immunohistochemical approaches. The findings reveal that Atlantic salmon with a systemic ISAV infection displayed ISAV antigen accumulation in specific ocular tissues and significant ocular morphological changes that could compromise visual acuity. Immunohistochemical analyses showed that ISAV\u2010related ocular pathological changes correlate with changes in expression levels and\/or spatial localizations of IgM, Sox6, Sox9, collagen type 1, Gata1, and CD10 in specific compartments of the eye. The cornea is likely one of the first ocular tissues to be exposed to the cohabitation\u2010mediated ISAV infection. The ISAV\u2010infected Atlantic salmon showed corneal dysplasia, which correlated with increased corneal stromal ISAV antigen expression, dysregulated IgM, Sox6, and collagen type 1 expression, and an induction of Sox9 expression at the corneal surface. The choroid rete mirabile of ISAV\u2010infected eyes showed a decreased complement of erythrocytes, consistent with anaemia, while Gata1 expression, a key mediator of erythropoiesis, was upregulated compared to non\u2010infected eyes, suggesting a potential erythropoietic compensatory response. These findings provide a basis for further study of ISAV\u2010mediated ocular pathological changes and new insight into the pathogenesis of orthomyxoviruses in the eye.<\/jats:p>","DOI":"10.1111\/jfd.70219","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:15:08Z","timestamp":1780373708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (\n                    <scp>\n                      <i>Salmo salar<\/i>\n                    <\/scp>\n                    )"],"prefix":"10.1111","volume":"49","author":[{"given":"Emily","family":"Mahon","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, Faculty of Medicine Memorial University of Newfoundland  St. John's Newfoundland Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca 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