{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:55:31Z","timestamp":1790862931033,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Anguillid herpesvirus (AngHV) is the causative agent of \u2018mucus sloughing and hemorrhagic septicemia disease\u2019 in eels. Egg yolk immunoglobulin (IgY) has been reported to serve as oral administration of antibodies against bacterial and viral pathogens. In this study, an inactivated vaccine of AngHV was developed to immunise the laying hens, thereby facilitating the production of anti\u2010AngHV IgY. The yolks were subsequently collected and processed into a dry yolk powder, and IgY was extracted from the yolk powder. The anti\u2010AngHV efficacy of the IgY was assessed through both in\u00a0vitro and in\u00a0vivo assays. In\u00a0vitro analyses showed that the purified IgY was capable of neutralizing AngHV in an antibody concentration\u2010dependent manner. In the in\u00a0vivo experiment, the incorporation of 6\u2030 yolk powder into the diet of eels exhibited no negative impact on growth performance, intestinal tissue morphology, intestinal microbiota, and metabolic profiles. However, the incidence of morbidity in AngHV\u2010infected eels decreased from 100% to 71%, while mortality rates declined from 57.14% to 28.57%. Additionally, the concentration of AngHV in the skin mucus was significantly reduced. This study provides the evidence that the anti\u2010AngHV IgY can effectively confer protection to eels against AngHV infection, thereby establishing a foundation for the development of anti\u2010AngHV therapy products using the yolk powder.<\/jats:p>","DOI":"10.1111\/jfd.70230","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:08:43Z","timestamp":1783055323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Passive Protective Effects of Chicken Egg Yolk Immunoglobulins (\n                    <scp>IgY<\/scp>\n                    ) Against Anguillid Herpesvirus Infection in American Eel (\n                    <i>Anguilla rostrata<\/i>\n                    )"],"prefix":"10.1111","volume":"49","author":[{"given":"Ying\u2010Ying","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Biotechnology Fujian Academy of Agricultural Sciences  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology Fujian Academy of Agricultural Sciences  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine Fujian Academy of Agricultural Sciences  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Xian","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology Fujian Academy of Agricultural Sciences  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-9872","authenticated-orcid":false,"given":"Jun\u2010Qing","family":"Ge","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology Fujian Academy of Agricultural Sciences  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2025.110898"},{"key":"e_1_2_10_3_1","first-page":"940","article-title":"Pathogenicity of Anguillid Herpesvirus to \n                     Anguilla anguilla","volume":"45","author":"Chen Q.","year":"2021","journal-title":"Journal of Fisheries of China"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2024.115014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.13907"},{"key":"e_1_2_10_6_1","article-title":"Oral Administration of Chivken Yolk Immunglobulins to Lower Somatic Cell Count in the Milk of Lactating Ruminants","volume":"98","author":"Coleman M. 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