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However, outbreaks of the hemorrhagic septicemic disease caused by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aeromonas veronii<\/jats:italic>\n                    <\/jats:styled-content>\n                    have led to substantial economic losses in Asian swamp eel culture and its pathogenesis remains poorly understood. Therefore, this study isolated a pathogenic bacterial strain from diseased fish, which was identified as\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009veronii<\/jats:italic>\n                    <\/jats:styled-content>\n                    and named the strain MaAv001 through phenotypic and 16S rRNA sequencing analyses. Artificial infection confirmed its high pathogenicity, with an LD\n                    <jats:sub>50<\/jats:sub>\n                    of 4.12\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    \u2009CFU\/g. Histopathological analysis revealed systemic damage, renal necrosis, splenic lymphocyte reduction, hepatic necrosis and intestinal sloughing. Virulence gene profiling identified six factors (\n                    <jats:italic>aer<\/jats:italic>\n                    ,\n                    <jats:italic>lip<\/jats:italic>\n                    ,\n                    <jats:italic>gcaT<\/jats:italic>\n                    ,\n                    <jats:italic>ser<\/jats:italic>\n                    ,\n                    <jats:italic>alt<\/jats:italic>\n                    ,\n                    <jats:italic>act<\/jats:italic>\n                    ) contributing to pathogenicity. The 16S rRNA of intestinal microbiota analysis revealed significant dysbiosis in the intestinal microbiota, marked by reduced beneficial\n                    <jats:italic>Sphingomonas<\/jats:italic>\n                    diversity and increased abundance of\n                    <jats:italic>Vibrio<\/jats:italic>\n                    . Non\u2010targeted metabolomics identified 646 differential metabolites enriched in sulfur relay, glutathione, seleno\u2010compound and cytochrome P450 pathways. This study elucidates the molecular pathogenesis of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A.\u2009veronii<\/jats:italic>\n                    <\/jats:styled-content>\n                    as a primary pathogen of hemorrhagic septicemia in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>M.\u2009albus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and its impact on the gut microbiome profiles and metabolomics. These findings provide a theoretical foundation for the diagnosis and prevention of\n                    <jats:italic>Aeromonas<\/jats:italic>\n                    infections in aquaculture.\n                  <\/jats:p>","DOI":"10.1111\/jfd.70244","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:12:58Z","timestamp":1784117578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intestinal Microbiota and Metabolomics Analysis of Asian Swamp Eel (\n                    <scp>\n                      <i>Monopterus albus<\/i>\n                    <\/scp>\n                    ) With Hemorrhagic Septicemia Caused by\n                    <scp>\n                      <i>Aeromonas veronii<\/i>\n                    <\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-9134","authenticated-orcid":false,"given":"Zeyu","family":"Feng","sequence":"first","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, College of Fisheries and Life Science Shanghai Ocean University  Shanghai China"},{"name":"National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, College of Fisheries and Life Science Shanghai Ocean University  Shanghai China"},{"name":"National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-1178","authenticated-orcid":false,"given":"Gelana Urgesa","family":"Ayana","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, College of Fisheries and Life Science Shanghai Ocean University  Shanghai China"},{"name":"National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, College of Fisheries and Life Science Shanghai Ocean University  Shanghai China"},{"name":"National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Laboratory Animal Research Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Academy of Agricultural Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, College of Fisheries and Life Science Shanghai Ocean University  Shanghai China"},{"name":"National Pathogen Collection Center for Aquatic Animals Shanghai Ocean University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaw1920"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1639646"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15330"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.Aquaculture.2021.736707"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.17582\/journal.pjz\/20181009061048"},{"key":"e_1_2_12_7_1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing. 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