{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:48:42Z","timestamp":1791607722475,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2024GXNSFFA010017"],"award-info":[{"award-number":["2024GXNSFFA010017"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2026GXNSFAA00640233"],"award-info":[{"award-number":["2026GXNSFAA00640233"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Singapore grouper iridovirus (SGIV) is a major viral pathogen threatening grouper aquaculture. The lack of specific antiviral drugs underscores the urgent need to develop safe and effective control strategies. This study demonstrates that tannic acid (TA) exhibits significant anti\u2010SGIV activity in\u00a0vitro. In grouper spleen (GS) cells, TA inhibited SGIV replication in a concentration\u2010dependent manner. Time\u2010of\u2010addition assays confirmed its antiviral efficacy when applied either before or after SGIV infection. Mechanistically, TA directly interfered with SGIV particle infectivity, viral adsorption, entry and intracellular replication. Network pharmacology analysis suggested TA's targets are associated with host cellular antioxidant pathways, among which Peroxiredoxin 6 (PRDX6) was identified as a potential target of TA. Further experiments confirmed that TA upregulated the Nrf2 antioxidant pathway and suppressed the expression of pro\u2010inflammatory cytokines (IL\u20101\u03b2, IL\u20108). Notably, TA enhanced the expression of PRDX6, and overexpression of PRDX6 significantly inhibited SGIV replication, indicating that PRDX6 contributes to the antiviral effect of TA. In\u00a0vivo, TA treatment not only restored PRDX6 expression in infected groupers but also significantly reduced viral load in liver and spleen following SGIV infection. These findings demonstrate that TA inhibits SGIV through direct viral interference and PRDX6\u2010mediated antioxidant modulation, highlighting its potential as a natural therapeutic agent against SGIV.<\/jats:p>","DOI":"10.1111\/jfd.70273","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T04:03:57Z","timestamp":1786593837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting Peroxiredoxin 6: Tannic Acid Inhibits Singapore Grouper Iridovirus Infection via PRDX6\u2010Dependent Pathway and Antioxidant Response"],"prefix":"10.1111","author":[{"given":"Xiangmou","family":"Qin","sequence":"first","affiliation":[{"name":"Guangxi Academy of Marine Sciences, Guangxi Laboratory of Oceanography, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Sciences  Nanning People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Ao","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Marine Sciences, Guangxi Laboratory of Oceanography, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Sciences  Nanning People's Republic of China"},{"name":"Guangdong Engineering Technology Research Center of Indigenous Valuable Fish Reproductive Regulation and Breeding, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Fisheries College, Guangdong Ocean University  Zhanjiang People's Republic of 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and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Sciences  Nanning People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Marine Sciences, Guangxi Laboratory of Oceanography, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Sciences  Nanning People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center of Indigenous Valuable Fish Reproductive Regulation and Breeding, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Fisheries College, Guangdong Ocean University  Zhanjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huapu","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Engineering Technology Research Center of Indigenous Valuable Fish Reproductive Regulation and Breeding, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Fisheries College, Guangdong Ocean University  Zhanjiang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ling","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northwest A&amp;F University  Yangling Shaanxi People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-1454","authenticated-orcid":false,"given":"Junxiang","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Marine Sciences, Guangxi Laboratory of Oceanography, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Sciences  Nanning People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangxi Academy of Marine Sciences, Guangxi Laboratory of Oceanography, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology (GERCFT), Guangxi Academy of Sciences  Nanning People's Republic of 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