{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:24:41Z","timestamp":1788265481917,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 1230068"],"award-info":[{"award-number":["FONDECYT 1230068"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["ANID INCAR2 CIA250009"],"award-info":[{"award-number":["ANID INCAR2 CIA250009"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Fish Diseases"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tenacibaculosis, caused by\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">Tenacibaculum dicentrarchi<\/jats:styled-content>\n                      ,\n                    <\/jats:italic>\n                    is an emerging bacterial disease affecting salmonid aquaculture worldwide; however, host\u2013pathogen interactions and the immune response of Atlantic salmon (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salmo salar<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) remain poorly understood. This study evaluated the expression of 20 immune\u2010related genes in Atlantic salmon experimentally infected by immersion with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T. dicentrarchi<\/jats:italic>\n                    <\/jats:styled-content>\n                    and in uninfected controls under identical conditions. The 10\u2010day challenge trial included sampling every two days (skin\/muscle, gills, spleen and head kidney) for gene expression analyses. Koch's postulates were fulfilled in the challenge with the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T. dicentrarchi<\/jats:italic>\n                    <\/jats:styled-content>\n                    TdCh06, which induced 40% cumulative mortality; deaths began at 2\u2009days post\u2010infection and continued until Day 7. Of the 20 genes analysed by RT\u2010qPCR, seven (MHC\u2010I, MHC\u2010II, Arg\u20101, IL\u20101\u03b2, IL\u20102, IL\u201010 and IFN\u2010\u03b11) were consistently detected across tissues and used for comparative analysis. The results show that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T. dicentrarchi<\/jats:italic>\n                    <\/jats:styled-content>\n                    induces a rapid but heterogeneous immune response in Atlantic salmon: the spleen exhibits an early, transient systemic response; the head kidney shows delayed but strong transcriptional activation; skin\/muscle displays early local activation with sustained IL\u20101\u03b2 and IFN\u2010\u03b11 expression; and gills show early mucosal activation with persistent IL\u20101\u03b2 induction. Overall, infection triggers a tissue\u2010specific response involving inflammatory, antigen\u2010presentation, interferon\u2010associated and macrophage\u2010related pathways, suggesting sustained immune stimulation rather than effective bacterial clearance. These findings shed light on the host\u2013pathogen interaction during tenacibaculosis and identify key immunological pathways involved in disease progression. Notably, the genes IL\u20101\u03b2, MHC\u2010I, MHC\u2010II, IFN\u2010\u03b11, IL\u20102, IL\u201010 and Arg\u20101 are proposed as potential transcriptional markers of infection, offering valuable tools to characterise host responses. Importantly, these markers may also be useful for evaluating vaccine efficacy against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T. dicentrarchi<\/jats:italic>\n                    <\/jats:styled-content>\n                    in future studies.\n                  <\/jats:p>","DOI":"10.1111\/jfd.70283","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:05:36Z","timestamp":1788264336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Response of Atlantic Salmon (\n                    <scp>\n                      <i>Salmo salar<\/i>\n                    <\/scp>\n                    ) Experimentally Infected by Immersion Challenge With\n                    <scp>\n                      <i>Tenacibaculum dicentrarchi<\/i>\n                    <\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5368-4475","authenticated-orcid":false,"given":"Ruben","family":"Avenda\u00f1o\u2010Herrera","sequence":"first","affiliation":[{"name":"Laboratorio de Organismos Acu\u00e1ticos y Biotecnolog\u00eda Acu\u00edcola Universidad Andr\u00e9s Bello  Vi\u00f1a del Mar Chile"},{"name":"Interdisciplinary Center for Aquaculture Research \u2013 Applied Research (INCAR<sup>2<\/sup>) Universidad Andr\u00e9s Bello  Vi\u00f1a del Mar Chile"},{"name":"Centro Investigaci\u00f3n Marina Quintay (CIMARQ) Universidad Andr\u00e9s Bello  Quintay Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-8813","authenticated-orcid":false,"given":"Camila","family":"Kossack","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Comparativa, Centro de Biotecnolog\u00eda Acu\u00edcola (CBA) Universidad de Santiago de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian A.","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Grupo de Marcadores Inmunol\u00f3gicos en Organismos Acu\u00e1ticos, Laboratorio de Gen\u00e9tica e Inmunolog\u00eda Molecular, Instituto de Biolog\u00eda Pontificia Universidad Cat\u00f3lica de Valpara\u00edso  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-6329","authenticated-orcid":false,"given":"Kevin","family":"Maisey","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda Comparativa, Centro de Biotecnolog\u00eda Acu\u00edcola (CBA) Universidad de Santiago de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.13984"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.70013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.006963"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12464"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12767"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.14606"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.13820"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3354\/dao071255"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102761.2006.00712.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251\u2010020\u201001196\u20100"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.016"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154898"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2021.100859"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13567\u2010019\u20100649\u20108"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.108747"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201008341\u20107"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.MICPATH.2014.08.008"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1254677"},{"key":"e_1_2_11_20_1","volume-title":"El Estado Mundial de la Pesca y la Acuicultura 2024. 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