{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:36Z","timestamp":1790616516149,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T00:00:00Z","timestamp":1373846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Program of the National Ministry of Health"},{"name":"PLA Grand Program on Clinical High and New Technology","award":["200902002-2"],"award-info":[{"award-number":["200902002-2"]}]},{"name":"PLA Grand Program on Clinical High and New Technology","award":["2010gxjs098"],"award-info":[{"award-number":["2010gxjs098"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>graphic<\/jats:alt-text><\/jats:graphic><\/jats:boxed-text><\/jats:p>Ursodeoxycholic acid (UDCA<\/jats:styled-content>) treatment is an effective medical therapy for patients with primary biliary cirrhosis (PBC<\/jats:styled-content>); however, 40% of PBC<\/jats:styled-content> patients show an incomplete response to the UDCA<\/jats:styled-content> therapy. This study aimed to investigate the safety and efficacy of umbilical cord\u2010derived mesenchymal stem cell (UC\u2010MSC<\/jats:styled-content>) transfusion in PBC<\/jats:styled-content> patients with an incomplete response to UDCA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a single\u2010arm trial that included seven PBC<\/jats:styled-content> patients with a suboptimal response to UDCA<\/jats:styled-content> treatment. UC<\/jats:styled-content>\u2010MSCs<\/jats:styled-content> were first cultured, and then 0.5\u2009\u00d7\u2009106<\/jats:sup> cells\/kg body weights were infused through a peripheral vein. UC<\/jats:styled-content>\u2010MSCs<\/jats:styled-content> were given three times at 4\u2010week intervals, and patients were followed up for 48 weeks. Primary outcomes were to evaluate the safety and feasibility of UC\u2010MSC<\/jats:styled-content> treatment, and secondary outcomes were to evaluate liver functions and patient's quality of life.<\/jats:p><\/jats:sec>Results<\/jats:title>No obvious side\u2010effects were found in the patients treated with UC<\/jats:styled-content>\u2010MSCs<\/jats:styled-content>. Symptoms such as fatigue and pruritus were obviously alleviated in most patients after UC\u2010MSC<\/jats:styled-content> treatment. There was a significant decrease in serum alkaline phosphatase and \u03b3\u2010glutamyltransferase levels at the end of the follow\u2010up period as compared with baseline. No significant changes were observed in serum alanine aminotransferase, aspartate aminotransferase, total bilirubin, albumin, prothrombin time activity, international normalized ratio, or immunoglobulin M levels. The Mayo risk score, a prognostic index, was also stable during the treatment and follow\u2010up period.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>UC\u2010MSC<\/jats:styled-content> transfusion is feasible and well tolerated in patients with PBC<\/jats:styled-content> who respond only partially to UDCA<\/jats:styled-content> treatment, thus representing a novel therapeutic approach for patients in this subgroup. A larger, randomized controlled cohort study is warranted to confirm the clinical efficacy of UC\u2010MSC<\/jats:styled-content> transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12029","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T04:54:41Z","timestamp":1373950481000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["A pilot study of umbilical cord\u2010derived mesenchymal stem cell transfusion in patients with primary biliary cirrhosis"],"prefix":"10.1111","volume":"28","author":[{"given":"Lifeng","family":"Wang","sequence":"first","affiliation":[{"name":"Research Center for Biological Therapy The Institute of Translational Hepatology Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Biological Therapy The Institute 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