{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:16:48Z","timestamp":1791393408480,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>In the gastric mucosa of portal hypertensive rats, adaptive cytoprotection against ethanol\u2010induced damage is impaired. The aim of this study was to determine relation between impaired adaptive cytoprotection and oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Portal hypertension was produced in male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats by inducing staged portal vein occlusion. Oxidative stress levels were evaluated by measuring malondialdehyde and nitrotyrosine levels in the rat gastric mucosa with or without 10% ethanol pretreatment. Inhibition of oxidative stress by an anti\u2010oxidant agent was estimated, and glutathione levels were also measured. Adaptive cytoprotection to 70% ethanol treatment was evaluated by measuring the gastric mucosal injury index in the presence or absence of the anti\u2010oxidant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The portal hypertensive gastric mucosa pretreated with 10% ethanol had significantly higher oxidative stress levels than the mucosa not pretreated with 10% ethanol. However, the sham\u2010operated gastric mucosa pretreated with 10% ethanol had significantly lower oxidative stress levels than the mucosa not pretreated with 10% ethanol. Pretreatment with 10% ethanol increased glutathione levels in the sham\u2010operated but not in the portal hypertensive gastric mucosa. Administration of the anti\u2010oxidant agent prior to 10% ethanol pretreatment significantly reduced oxidative stress levels, increased glutathione levels, and decreased the injury index in response to 70% ethanol in the portal hypertensive gastric mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased oxidative stress may lead to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rats, probably through damage to the system of endogenous anti\u2010oxidant production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12101","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T11:42:17Z","timestamp":1356608537000},"page":"639-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased oxidative stress may lead to impaired adaptive cytoprotection in the gastric mucosa of portal hypertensive rat"],"prefix":"10.1111","volume":"28","author":[{"given":"Yuichiro","family":"Kawano","sequence":"first","affiliation":[{"name":"Department of Surgery I Oita University Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Surgery I Oita University Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery I Oita University Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Iwashita","sequence":"additional","affiliation":[{"name":"Department of Surgery I Oita University Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Surgery I Oita University Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Surgery I Oita University Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.11.1226"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.119499"},{"key":"e_1_2_6_4_1","first-page":"79","article-title":"The portal hypertensive gastric mucosa: histologic, ultrastructural, and functional analysis after aspirin\u2010induced damage","volume":"104","author":"Sarfeh IJ","year":"1998","journal-title":"Surgery"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536055"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90705-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90335-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90329.2008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.06.029"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00196-8"},{"key":"e_1_2_6_11_1","first-page":"G113","article-title":"Mild irritants prevent gastric necrosis through \u201cadaptive cytoprotection\u201d mediated by plostaglandis","volume":"245","author":"Robert A","year":"1983","journal-title":"Am. 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