{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:04:39Z","timestamp":1780049079158,"version":"3.53.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC 98-2628-B-075B-001-MY2"],"award-info":[{"award-number":["NSC 98-2628-B-075B-001-MY2"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"name":"E-DA Hospital","award":["EDPJ 99019"],"award-info":[{"award-number":["EDPJ 99019"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopic therapy combined with vasoconstrictor was generally recommended to treat acute variceal bleeding. However, up to 30% of patients may still encounter treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This trial was to evaluate the efficacy of combination with endoscopic variceal ligation (<jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content>) and proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) infusion in patients with acute variceal bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cirrhotic patients presenting with acute esophageal variceal bleeding were rescued by emergency <jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content>. Soon after arresting of bleeding varices, eligible subjects were randomized to two groups. Vasoconstrictor group received either somatostatin or terlipressin infusion. <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group received either omeprazole or pantoprazole. End points were initial hemostasis, very early rebleeding rate, and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were enrolled in vasoconstrictor group and 58 patients in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group. Both groups were comparable in baseline data. Initial hemostasis was achieved in 98% in vasoconstrictor group and 100% in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u2009=\u20091.0). Very early rebleeding within 48\u2013120\u2009h occurred in one patient (2%) in vasoconstrictor group and one patient (2%) in the <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u2009=\u20091.0). Treatment failure was 4% in vasoconstrictor group and 2% in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u2009=\u20090.95). Adverse events occurred in 33 patients (55%) in vasoconstrictor group and three patients (6%) in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Two patients in vasoconstrictor group and one patient in <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group encountered esophageal ulcer bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>After successful control of acute variceal bleeding by <jats:styled-content style=\"fixed-case\">EVL<\/jats:styled-content>, adjuvant therapy with <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> infusion was similar to combination with vasoconstrictor infusion in terms of initial hemostasis, very early rebleeding rate, and associated with fewer adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12107","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T11:42:29Z","timestamp":1356608549000},"page":"684-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Controlled trial of ligation plus vasoconstrictor <i>versus<\/i> proton pump inhibitor in the control of acute esophageal variceal bleeding"],"prefix":"10.1111","volume":"28","author":[{"given":"Gin\u2010Ho","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Medical Research, Digestive Center E\u2010DA Hospital"},{"name":"Division of Gastroenterology Department of Medicine I\u2010Shou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daw\u2010Shyong","family":"Perng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine I\u2010Shou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yang","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine I\u2010Shou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Ming","family":"Tai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine I\u2010Shou University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huay\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Medicine I\u2010Shou University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300222"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508313330904"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05099-X"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440104"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165910"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31354"},{"key":"e_1_2_4_8_1","first-page":"419","volume-title":"Schiff's Diseases of the Liver","author":"Bosch J","year":"2007"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250509"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988831.ch9"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(93)70049-8"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220215"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.16236"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20593"},{"key":"e_1_2_4_16_1","first-page":"365","article-title":"Prophylactic antibiotics in cirrhotics with upper gastrointestinal hemorrhage: a prospective, controlled trial","volume":"65","author":"Lin YT","year":"2002","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20126"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(10)70009-7"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80320-7"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988831.ch2"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00430-0"},{"key":"e_1_2_4_22_1","first-page":"1403","article-title":"Prognostic values of early measurements of portal pressure in acute variceal bleeding","volume":"100","author":"Moitinho E","year":"1991","journal-title":"Gastroenterology"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.060"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199812000-00010"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02050-4"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92840-5"},{"key":"e_1_2_4_27_1","article-title":"Combination of somatostatin plus endoscopic variceal ligation (EVL) is similar to EVL alone in control of acute variceal bleeding: a randomized controlled trial [Abstract]","volume":"628","author":"Sarin SK","year":"2008","journal-title":"Hepatology"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(88)71274-2"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.032"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.114061"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.40665.x"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910102"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20236"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840100304"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.147"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.016"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.11.019"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898643"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20339"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:05:33Z","timestamp":1697342733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,25]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/jgh.12107"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12107","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,25]]},"assertion":[{"value":"2012-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}