{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:10:07Z","timestamp":1745964607987,"version":"3.40.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Aphthous stomatitis is one of the adverse effects associated with interferon (IFN) that forces dose reduction of<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>and there is no established therapy. This study was aimed to investigate whether irsogladine maleate, which enhances the functions of intercellular communication through the gap junctions, is effective for the treatment of aphthous stomatitis developed in hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) patients on pegylated\u2010interferon (<jats:styled-content style=\"fixed-case\">PEG\u2010IFN<\/jats:styled-content>) and ribavirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen patients with<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>were treated with<jats:styled-content style=\"fixed-case\">PEG\u2010IFN<\/jats:styled-content>and ribavirin for 48 weeks. Ten out of 19 patients developed aphthous stomatitis during treatment with<jats:styled-content style=\"fixed-case\">PEG\u2010IFN<\/jats:styled-content>and ribavirin. Within 1\u20132 weeks after development of aphthous stomatitis, 4\u2009mg irsogladine maleate was orally administered daily to all patients and the therapeutic and adverse effects of irsogladine maleate were examined on every week. The degree of aphthous stomatitis was evaluated by Common Terminology Criteria for Adverse Events (<jats:styled-content style=\"fixed-case\">CTCAE<\/jats:styled-content>) version 4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 10 patients, aphthous stomatitis was evaluated as grade 3 in three patients (30%) and grade 2 in seven patients (70%) by<jats:styled-content style=\"fixed-case\">CTCAE<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">CTCAE<\/jats:styled-content>grade was improved to 0 after 1 week in six patients, after 2 weeks in two patients, and after 3 weeks in two patients after the start of administration of irsogladine maleate. Aphthous stomatitis has not recurred in patients who had been on irsogladine maleate continuously during treatment of<jats:styled-content style=\"fixed-case\">PEG\u2010IFN<\/jats:styled-content>and ribavirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Irsogladine maleate is effective for the treatment of aphthous stomatitis developing during<jats:styled-content style=\"fixed-case\">PEG\u2010IFN<\/jats:styled-content>and ribavirin administration in<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12137","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T07:58:52Z","timestamp":1361433532000},"page":"1015-1018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis<scp>C<\/scp>virus patients on pegylated\u2010interferon and ribavirin: A pilot study"],"prefix":"10.1111","volume":"28","author":[{"given":"Nobuhiko","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"George","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisakazu","family":"Shiroeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Toshikuni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsumi","family":"Tsuchishima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomiyasu","family":"Arisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikihiro","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kanazawa Medical University Uchinada Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G263"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000118903.35704.30"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct061675"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.93.314"},{"key":"e_1_2_5_6_1","first-page":"478","article-title":"Effect of 2,4\u2010diamino\u20106\u2010(2,5\u2010dichlorophenyl)\u2010s\u2010triazine maleate (MN\u20101695) on gastric mucosal damage induced by various necrotizing agents in rats","volume":"34","author":"Ueda F","year":"1984","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.57.321"},{"key":"e_1_2_5_8_1","first-page":"587","article-title":"Clinical effect of irsogladine maleate for aphthous stomatitis","volume":"164","author":"Hosokawa T","year":"1993","journal-title":"Prog. 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