{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:37:52Z","timestamp":1781566672886,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Liver Institute, Menofiya University, Egypt"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Diagnosis of biliary atresia (BA<\/jats:styled-content>), particularly distinguishing it from other causes of neonatal cholestasis (NC<\/jats:styled-content>), is challenging. Ultrasonography is a helpful investigation when evaluating NC<\/jats:styled-content>. The aim was to determine the value of color D<\/jats:styled-content>oppler ultrasound, particularly hepatic subcapsular flow, as a possible tool in early discrimination of BA<\/jats:styled-content> from other causes of NC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ultrasonographic and color D<\/jats:styled-content>oppler findings of 27 BA<\/jats:styled-content> patients were compared with that in 27 non\u2010BA<\/jats:styled-content> cholestasis patients and a control group of 22 non\u2010hepatic neonates.<\/jats:p><\/jats:sec>Results<\/jats:title>Hepatic artery diameter was significantly higher in BA<\/jats:styled-content> (2.48\u2009\u00b1\u20090.55\u2009mm) than that in non\u2010BA<\/jats:styled-content> group (1.91\u2009\u00b1\u20090.63\u2009mm) (P<\/jats:italic>\u2009=\u20090.001) and the control group (1.6\u2009\u00b1\u20090.47\u2009mm) (P<\/jats:italic>\u2009<\u20090.0001), while there were no statistically significant difference between BA<\/jats:styled-content> and non\u2010BA<\/jats:styled-content> groups as regards portal vein diameter and flow, hepatic vein flow, and hepatic artery resistance index. The frequency of hepatic subcapsular flow was significantly higher in BA<\/jats:styled-content> than that in non\u2010BA<\/jats:styled-content> group (96.3% vs<\/jats:italic> 3.7%; P<\/jats:italic>\u2009<\u20090.0001), while it was not detected in any of the non\u2010hepatic control group. The presence of hepatic subcapsular flow had 96.3% sensitivity and specificity in predicting BA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Color D<\/jats:styled-content>oppler ultrasound findings could help significantly in discriminating BA<\/jats:styled-content> from other causes of NC<\/jats:styled-content>, among which hepatic subcapsular flow had the best performance. Considering the young age of BA<\/jats:styled-content> patients (61.8\u2009\u00b1\u200915.1 days), hepatic subcapsular flow can help in early diagnosis of BA<\/jats:styled-content> and prevent the delay in surgical correction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12151","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T07:59:11Z","timestamp":1361433551000},"page":"867-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Value of hepatic subcapsular flow by color D<\/scp>oppler ultrasonography in the diagnosis of biliary atresia"],"prefix":"10.1111","volume":"28","author":[{"given":"Mohamed Abdel\u2010Salam","family":"El\u2010Guindi","sequence":"first","affiliation":[{"name":"Department of Pediatric Hepatology National Liver Institute, Menofiya University Shebin El\u2010koom Menofiya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa Mohamed","family":"Sira","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology National Liver Institute, Menofiya University Shebin El\u2010koom Menofiya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem Abdel\u2010Sattar","family":"Konsowa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology National Liver Institute, Menofiya University Shebin El\u2010koom Menofiya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Lotfi","family":"El\u2010Abd","sequence":"additional","affiliation":[{"name":"Department of Radiology National Liver Institute, Menofiya University Shebin El\u2010koom Menofiya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahany Abdel\u2010Hameed","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology National Liver Institute, Menofiya University Shebin El\u2010koom Menofiya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01464.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-20060401-13"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-28"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05114.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.08.035"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199302000-00001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01338.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3108"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0171-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05737.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2443061051"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90650-4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199301000-00010"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2452061093"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522080923"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230652"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.01.003"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22182"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3495"},{"key":"e_1_2_5_21_1","first-page":"716","article-title":"Value of gamma\u2010glutamyl transpeptidase for early diagnosis of biliary atresia","volume":"61","author":"Liu CS","year":"1998","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_2_5_22_1","first-page":"107","article-title":"Extra\u2010hepatic biliary atresia: diagnostic methods","volume":"79","author":"Cauduro S","year":"2003","journal-title":"J. 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