{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:53:54Z","timestamp":1776704034124,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver transplantation remains the best option for treating type\u20101 hepatorenal syndrome (<jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>1). The aim of this retrospective study was to determine whether the molecular adsorbent recirculation system (MARS) can improve renal function in HRS1 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients with chronic liver disease and <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>1 were treated by <jats:styled-content style=\"fixed-case\">MARS<\/jats:styled-content> sessions which were performed every other day. The endpoint was renal function improvement by 28 days after diagnosis of <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>1 that was defined as a serum\u2010creatinine level of &lt;\u2009133\u2009\u03bcmol\/L. Partial renal recovery was defined as a 10% decrease in baseline serum\u2010creatinine level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean number of <jats:styled-content style=\"fixed-case\">MARS<\/jats:styled-content> sessions required by each patient was 3.5\u2009\u00b1\u20091.5. The median time between admission and the start of <jats:styled-content style=\"fixed-case\">MARS<\/jats:styled-content> therapy was 3 (0\u201315) days. Of the total patients, 13 (40%) had improved renal function. Among these, nine (28%) had complete renal recovery. Among the patients that survived, only 40% (6\/15) had improved renal function, and among the patients that died within the first month after the initiation of <jats:styled-content style=\"fixed-case\">MARS<\/jats:styled-content>, seven patients had a renal response. The 28\u2010day survival rate was 47%. Seven patients received a liver transplant after diagnosis of <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>. Of these, four had complete or partial recovery after transplantation (57%) versus 9 of the 25 patients who did not undergo liver transplantation (36%), <jats:italic>P<\/jats:italic>\u2009=\u2009not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MARS<\/jats:styled-content> therapy improved renal function in only very few patients with <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>1. Further controlled studies including large number of patients are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12159","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T08:00:47Z","timestamp":1361433647000},"page":"1019-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Impact of molecular adsorbent recirculating system on renal recovery in type\u20101 hepatorenal syndrome patients with chronic liver failure"],"prefix":"10.1111","volume":"28","author":[{"given":"Laurence","family":"Lavayssi\u00e8re","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siba","family":"Kallab","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Cardeau\u2010Desangles","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie B\u00e9atrice","family":"Nogier","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Cointault","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Barange","sequence":"additional","affiliation":[{"name":"Department of Hepatology CHU Purpan  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Muscari","sequence":"additional","affiliation":[{"name":"Department of Liver Transplantation CHU Rangueil  France"},{"name":"Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Rostaing","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"},{"name":"INSERM U1043 IFR\u2013BMT CHU Purpan  France"},{"name":"Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Organ Transplantation CHU Rangueil  France"},{"name":"INSERM U1043 IFR\u2013BMT CHU Purpan  France"},{"name":"Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/00042737-199909000-00021","article-title":"Hepatorenal syndrome and its treatment today","volume":"11","author":"Gentilini P","year":"1999","journal-title":"Eur. 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