{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:57:42Z","timestamp":1754110662143},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>The cytotoxic T<\/jats:styled-content>\u2010lymphocyte antigen 4 (CTLA<\/jats:styled-content>4) gene polymorphisms have been shown to be associated with the risk of primary biliary cirrhosis (PBC<\/jats:styled-content>). The study aimed to confirm the associations of CTLA<\/jats:styled-content>4 gene polymorphisms with risk of PBC<\/jats:styled-content> and patients' quality of life in C<\/jats:styled-content>hinese population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 312 female PBC<\/jats:styled-content> patients from C<\/jats:styled-content>hinese H<\/jats:styled-content>an population were included as case, and 375 age\u2010matched female healthy volunteers were included as control. Four single nucleotide polymorphisms (SNPs<\/jats:styled-content>) including rs231775, rs3087243, rs231725, and rs5742909 were genotyped. The differences of genotype and allele distributions between PBC<\/jats:styled-content> patients and healthy controls were assessed. The relationship between CTLA<\/jats:styled-content>4 gene polymorphisms and healthy status of PBC<\/jats:styled-content> patients were then investigated through comparisons of the domain scores of PBC<\/jats:styled-content>\u201040 questionnaire between different genotype categories of each single nucleotide polymorphism.<\/jats:p><\/jats:sec>Results<\/jats:title>The frequencies of G<\/jats:styled-content> allele at rs231775 and A<\/jats:styled-content> allele at rs231725 were both significantly increased in PBC<\/jats:styled-content> patients when compared with normal controls (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001, odds ratio\u2009=\u20091.44, 95% confidence interval\u2009=\u20091.24\u20131.67 for rs231775; P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001, odds ratio\u2009=\u20091.29, 95% confidence interval\u2009=\u20091.12\u20131.48 for rs231725). Besides, patients carrying A<\/jats:styled-content> allele of rs3087243 had significantly lower score of fatigue domain than those carrying G<\/jats:styled-content> allele (2.5\u2009\u00b1\u20090.8 vs<\/jats:italic> 3.9\u2009\u00b1\u20091.3, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study revealed that CTLA<\/jats:styled-content>4 gene polymorphism might be associated with susceptibility of PBC<\/jats:styled-content>. G<\/jats:styled-content> allele of rs231775 and A<\/jats:styled-content> allele of rs231725 were significantly associated with the risk of PBC<\/jats:styled-content>. In addition, patients carrying A<\/jats:styled-content> allele of rs3087243 could have significantly better quality of life than those carrying G<\/jats:styled-content> allele.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12165","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:10:14Z","timestamp":1361549414000},"page":"1397-1402","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between cytotoxic T<\/scp>\u2010lymphocyte antigen 4 gene polymorphisms and primary biliary cirrhosis in C<\/scp>hinese population: data from a multicenter study"],"prefix":"10.1111","volume":"28","author":[{"given":"Qianjun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Huai'an First People's Hospital of Nanjing Medical University Huai'an 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Drum Tower Hospital of Nanjing University Medical School Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Huai'an First People's Hospital of Nanjing Medical University Huai'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Huai'an First People's Hospital of Nanjing Medical University Huai'an 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