{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:01:47Z","timestamp":1773860507258,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Epidemiology of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection has regional variation. Effect of eradication of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> on symptoms of functional dyspepsia is uncertain, and the data in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian scenario are scanty. The study aimed to see <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> positivity rate in patients of functional dyspepsia and the effect of its eradication on symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized, double\u2010blind, placebo\u2010controlled study was the study design used. Patients of functional dyspepsia defined as per <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ome 2 criteria were tested for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> infection by rapid urease test and gastric biopsy. <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010positive patients were randomly allocated to triple therapy (20\u2009mg of omeprazole, 500\u2009mg of clarithromycin, and 1000\u2009mg of amoxicillin orally two times daily) and omeperazole plus identical placebo for 2 weeks. Symptoms were assessed with the weekly <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ikert scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> positivity rate in functional dyspepsia was 1160\/2000 (58%). At 6 weeks, the eradication rate for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> in triple therapy and placebo group was (181\/259 [69.8%] and 13\/260 [5.0%], <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001), respectively. On intention\u2010to\u2010treat analysis, the symptom resolution at 1 month was (157\/259 [60.7%] and 136\/260 [52.3%], <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.38), respectively. At 12 months, <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> eradication and healing of gastritis in triple therapy and placebo group were (116\/174 [66.7%] and 12\/180 [6.7%], <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001) and (132\/174 [75.9%] and 11\/180 [6.1%], <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.001), respectively. On intension to treat, the resolution of symptoms in triple therapy and placebo group was (95\/217 [43.7%] and 72\/195 [36.9%], <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is high <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> positivity rate in patients of functional dyspepsia. The eradication of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u2009pylori<\/jats:italic> does not resolve the symptoms despite healing of gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12178","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T16:10:21Z","timestamp":1361549421000},"page":"808-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Prevalence of <i><scp>H<\/scp>elicobacter pylori<\/i> infection and the effect of its eradication on symptoms of functional dyspepsia in <scp>K<\/scp>ashmir, <scp>I<\/scp>ndia"],"prefix":"10.1111","volume":"28","author":[{"given":"Jaswinder Singh","family":"Sodhi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gul","family":"Javid","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Showkat Ali","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Tufail","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altaf","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashir Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam Nabi","family":"Yattoo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam Mohamad","family":"Gulzar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushtaq Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Iqbal","family":"Lone","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyaz u","family":"Saif","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaheena","family":"Parveen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Shoukat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sher\u2010i\u2010Kashmir Institute of Medical Sciences  Srinagar Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"145","article-title":"Functional dyspepsia: a classification with guidelines for diagnosis and management","volume":"4","author":"Talley NJ","year":"1991","journal-title":"Gastroenterol. 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