{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:11:09Z","timestamp":1696223469000},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>A major use of breath hydrogen testing is to assess absorptive capacity for sugars to assist dietary design for management of gut symptoms. Qualitative reporting takes no account of the vigor of hydrogen response and provides little insight into degrees of malabsorption. This study aimed to describe a semiquantitative reporting method and to compare results with those reported qualitatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In consecutive <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian patients with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease (<jats:italic>n<\/jats:italic>\u2009=\u200987), ulcerative colitis (59), functional gastrointestinal disorders (<jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content>) (162), and healthy controls (76), area under the curve was calculated for lactulose (15\u2009g). This was compared with that for lactose (50\u2009g) and fructose (35\u2009g). Degree of malabsorption was categorized into arbitrary groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Semiquantitative results for \u2265\u200930% (designated \u201cconvincing\u201d) malabsorption was most similar to those using a qualitative cutoff value of 20\u2009ppm, but in 38% and 21% of patients, the classification of malabsorption (nil or clinically significant) changed for fructose and lactose, respectively. Using a cutoff of 10\u2009ppm, 49% and 5% were classified differently. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease had a higher prevalence (42%) of convincing fructose malabsorption than controls (24%) or patients with <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content> (33%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02). Highest prevalence of convincing lactose malabsorption (38%) was in ulcerative colitis, greater than controls (18%) and <jats:styled-content style=\"fixed-case\">FGID<\/jats:styled-content> (18%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Semiquantitative assessment provides different results with different clinical implications in more than one third of patients, but disease\u2010related alterations in prevalence are similar to those defined qualitatively. This method may be preferable because it lessens the confounding influence of the vigor of the hydrogen response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12199","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T12:59:04Z","timestamp":1363870744000},"page":"1450-1456","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Semiquantitative assessment of breath hydrogen testing"],"prefix":"10.1111","volume":"28","author":[{"given":"Jacqueline S","family":"Barrett","sequence":"first","affiliation":[{"name":"Monash University Eastern Health Clinical School  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya","family":"Kalubovila","sequence":"additional","affiliation":[{"name":"Monash University Eastern Health Clinical School  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M","family":"Irving","sequence":"additional","affiliation":[{"name":"Monash University Eastern Health Clinical School  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R","family":"Gibson","sequence":"additional","affiliation":[{"name":"Monash University Eastern Health Clinical School  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06149.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.058"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04237.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06370.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00457.2010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.10.1161"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-12-201006150-00241"},{"key":"e_1_2_5_9_1","first-page":"1","article-title":"Lactose intolerance and health","volume":"192","author":"Wilt TJ","year":"2010","journal-title":"Evid. 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