{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:49:23Z","timestamp":1787240963687,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n Functional dyspepsia (\n FD<\/jats:styled-content>\n ) is an important gastrointestinal problem with obscure etiology. Abnormal gastric motility is suggested as a possible pathophysiological mechanism for symptoms. The main objective of this study was to assess gastric motility in\n S<\/jats:styled-content>\n ri\n L<\/jats:styled-content>\n ankan children with\n FD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty\u2010one children (19 [46.3%] males, age 4\u201314 years, mean 7.5 years,\n SD<\/jats:styled-content>\n 2.6 years) referred to the\n G<\/jats:styled-content>\n astroenterology\n R<\/jats:styled-content>\n esearch\n L<\/jats:styled-content>\n aboratory,\n F<\/jats:styled-content>\n aculty of\n M<\/jats:styled-content>\n edicine,\n U<\/jats:styled-content>\n niversity of\n K<\/jats:styled-content>\n elaniya, from\n J<\/jats:styled-content>\n anuary 2007 to\n D<\/jats:styled-content>\n ecember 2011, were screened. Those fulfilling\n R<\/jats:styled-content>\n ome\n III<\/jats:styled-content>\n criteria for\n FD<\/jats:styled-content>\n were recruited. None had clinical or laboratory evidence of organic disorders. Twenty healthy children were recruited as controls (eight [40%] males, age 4\u201314 years, mean 8.4 years,\n SD<\/jats:styled-content>\n 3.0 years). Liquid gastric emptying rate (\n GE<\/jats:styled-content>\n ) and antral motility parameters were assessed using an ultrasound\u2010based method.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Average\n GE<\/jats:styled-content>\n (45.6%\n vs<\/jats:italic>\n 66.2% in controls), amplitude of antral contractions (58.2%\n vs<\/jats:italic>\n 89.0%) and antral motility index (5.1\n vs<\/jats:italic>\n 8.3) were lower and fasting antral area (1.5\u2009cm\n 2<\/jats:sup>\n vs<\/jats:italic>\n 0.6\u2009cm\n 2<\/jats:sup>\n ) was higher in patients with\n FD<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009<\u20090.01). Frequency of antral contractions (8.8\n vs<\/jats:italic>\n 9.3) did not show a significant difference (\n P<\/jats:italic>\n \u2009=\u20090.07). Scores obtained for severity of abdominal pain negatively correlated with\n GE<\/jats:styled-content>\n (r\u2009=\u2009\u22120.35,\n P<\/jats:italic>\n \u2009=\u20090.025). Children with\n FD<\/jats:styled-content>\n , exposed to stressful events had higher fasting antral area (1.9\u2009cm\n 2<\/jats:sup>\n ) than those not exposed to stress (1.0\u2009cm\n 2<\/jats:sup>\n ) (\n P<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n GE<\/jats:styled-content>\n and antral motility parameters were significantly impaired in children with\n FD<\/jats:styled-content>\n compared with controls.\n GE<\/jats:styled-content>\n negatively correlated with severity of symptoms. This study points to disturbances in gastric motility as an etiological factor for\n FD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12205","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T09:11:21Z","timestamp":1363857081000},"page":"1161-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Gastric emptying and antral motility parameters in children with functional dyspepsia: Association with symptom severity"],"prefix":"10.1111","volume":"28","author":[{"given":"Niranga Manjuri","family":"Devanarayana","sequence":"first","affiliation":[{"name":"Department of Physiology University of Kelaniya Ragama Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaman","family":"Rajindrajith","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Faculty of Medicine University of Kelaniya Ragama Sri 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