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Among them, intestinal metaplasia is frequently encountered in our daily endoscopic examination, yet its clinical significance is often underestimated despite of a number of reports demonstrating genetic and epigenetic alterations in the intestinal metaplastic mucosa. In this review, I will describe the molecular mechanisms of phenotypic changes from gastric mucosa to intestinal metaplasia based on our analysis of mouse model of intestinal metaplasia generated by ectopic expression of <jats:styled-content style=\"fixed-case\">CDX2<\/jats:styled-content> in conjunction with the studies with human intestinal metaplasia.<\/jats:p>","DOI":"10.1111\/jgh.12209","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T12:13:40Z","timestamp":1365164020000},"page":"906-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Premalignant conditions of gastric cancer"],"prefix":"10.1111","volume":"28","author":[{"given":"Kentaro","family":"Sugano","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology Jichi Medical University  Tochigi 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