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This study aimed to evaluate the gastroprotective effect of an ethanolic extract of<jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>.\u2009olitorius<\/jats:italic>against ethanol\u2010induced gastric ulcers in adult<jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley<\/jats:italic>rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The rats were divided into seven groups according to their pretreatment: an untreated control group, an ulcer control group, a reference control group (20\u2009mg\/kg omeprazole), and four experimental groups (50, 100, 200, or 400\u2009mg\/kg of extract). Carboxymethyl cellulose was the vehicle for the agents. Prior to the induction of gastric ulcers with absolute ethanol, the rats in each group were pretreated orally. An hour later, the rats were sacrificed, and gastric tissues were collected to evaluate the ulcers and to measure enzymatic activity. The tissues were subjected to histological and immunohistochemical evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the extensive mucosal damage in the ulcer control group, gross evaluation revealed a marked protection of the gastric mucosa in the experimental groups, with significantly preserved gastric wall mucus. In these groups, superoxide dismutase and malondialdehyde levels were significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), respectively. In addition to the histologic analyses (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>and periodic acid\u2010Schiff staining), immunohistochemistry confirmed the protection through the upregulation of<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>sp70 and the downregulation of<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ax proteins. The gastroprotection of the experimental groups was comparable to that of the reference control medicine omeprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study reports the gastroprotective property of an ethanolic extract of<jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>.\u2009olitorius<\/jats:italic>against ethanol\u2010induced gastric mucosal hemorrhagic lesions in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12229","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T12:16:54Z","timestamp":1366719414000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["<i>Retracted<\/i>: Gastroprotective effects of<i><scp>C<\/scp>orchorus olitorius<\/i>leaf extract against ethanol\u2010induced gastric mucosal hemorrhagic lesions in rats"],"prefix":"10.1111","volume":"28","author":[{"given":"Rami","family":"Al Batran","sequence":"first","affiliation":[{"name":"Center of Studies for Periodontology Faculty of Dentistry University Technology Mara Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Al\u2010Bayaty","sequence":"additional","affiliation":[{"name":"Center of Studies for Periodontology Faculty of Dentistry University Technology Mara Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Ameen Abdulla","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen M","family":"Jamil Al\u2010Obaidi","sequence":"additional","affiliation":[{"name":"Center of Studies for Periodontology Faculty of Dentistry University Technology Mara Shah Alam Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hajrezaei","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"},{"name":"Institute of Biological Science Faculty of Science University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Hassandarvish","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Fouad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Golbabapour","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"},{"name":"Institute of Biological Science Faculty of Science University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Talaee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_6_3_1","first-page":"354","article-title":"Attenuation of acetic Acid\u2010induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors","volume":"58","author":"Nakashita M","year":"2013","journal-title":"Dig. 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