{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:50:50Z","timestamp":1761630650859},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labour and Welfare of Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Liver cirrhosis (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>) is accompanied by hepatic arterializations, intrahepatic shunts, and hyperdynamic circulations. These changes shorten the arrival time (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>) of ultrasound contrast agents to the hepatic vein (<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>). Whether treatment of gastric fundal varices (<jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>s) by balloon\u2010occluded transvenous obliteration (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RTO<\/jats:styled-content>) improves the <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients was prospectively investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>s and 10 normal controls (<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s) were enrolled. This study was approved by the clinical research ethics committee. Images of hepatic artery (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>), portal vein (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>), and <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content> were monitored after an injection of a contrast agent using quantification software. The <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> before and after <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RTO<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients and that in <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All <jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>s were treated effectively, and indocyanine green retention rate was improved (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.0001). The mean values of the <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">HV AT<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s were 21.9\u2009\u00b1\u20093.3, 28.2\u2009\u00b1\u20092.0, and 40.5\u2009\u00b1\u20092.1\u2009s, respectively. Those in <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients were 17.4\u2009\u00b1\u20094.4, 21.9\u2009\u00b1\u20095.6, and 26.3\u2009\u00b1\u20096.7, respectively, which were shorter than those in <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>s (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.002, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.0001, respectively). However, these <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s were significantly prolonged 1 week after <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RTO<\/jats:styled-content>, with mean values of 18.7\u2009\u00b1\u20094.8, 23.8\u2009\u00b1\u20096.0, and 30.0\u2009\u00b1\u20097.2\u2009s (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.043, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.01, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obliteration of <jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>s shifted the <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients to the normalization, raising the possibility of improvement of arterialization and intrahepatic shunt.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12234","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T11:39:24Z","timestamp":1366717164000},"page":"1526-1531","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Obliteration of gastric varices improves the arrival time of ultrasound contrast agents in hepatic artery and vein"],"prefix":"10.1111","volume":"28","author":[{"given":"Yoshihiro","family":"Furuichi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Moriyasu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatomo","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sofuni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80326-2"},{"key":"e_1_2_6_3_1","first-page":"975","article-title":"Portographic opacification of hepatic veins and anomalous anastomoses between the portal and hepatic veins in cirrhosis\u2014indication of extensive intrahepatic shunts","volume":"81","author":"Ohnishi K","year":"1986","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(90)90061-U"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(64)90066-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06373-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.8.1188"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.030965"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80180-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90501-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00010.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma25349"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2009.00929.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.1997.tb00692.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230104"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130525"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i40.6348"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00264-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2006.08.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.3748\/wjg.v11.i40.6348","article-title":"Hemodynamic and morphologic changes of peripheral hepatic vasculature in chronic liver disease: a preliminary study by contrast\u2010enhanced coded phase\u2010inversion harmonic sonography","volume":"11","author":"Sakaguchi Y","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05549.x"},{"key":"e_1_2_6_22_1","first-page":"40","article-title":"Portal hyperfusion or hepatic venous congestion: which one affects Kupffer cell function more?","volume":"7","author":"Firat O","year":"2009","journal-title":"Exp. Clin. Transplant."},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.234542"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05134.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.09.013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2009.05.013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00670.x"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12234","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:22:21Z","timestamp":1696206141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,22]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/jgh.12234"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12234","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,22]]},"assertion":[{"value":"2013-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}