{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:19Z","timestamp":1790517379302,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005992","name":"Ministry of Education, Culture, and Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Japan"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aims<\/jats:title>\n \n The association between functional dyspepsia (\n FD<\/jats:styled-content>\n ) and sleep disorders has yet to be studied in detail. The aim of this study is to evaluate the risk factors associated with sleep disorders and the clinical response to nizatidine therapy for sleep disorders in\n R<\/jats:styled-content>\n ome\n III<\/jats:styled-content>\n \u2010based\n FD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We enrolled 94\n FD<\/jats:styled-content>\n patients and 52 healthy volunteers. We used\n R<\/jats:styled-content>\n ome\n III<\/jats:styled-content>\n criteria to evaluate upper abdominal symptoms, and the Self\u2010Rating Questionnaire for Depression scores to determine depression status. Sleep disorder was evaluated using\n P<\/jats:styled-content>\n ittsburgh\n S<\/jats:styled-content>\n leep\n Q<\/jats:styled-content>\n uality\n I<\/jats:styled-content>\n ndex (\n PSQI<\/jats:styled-content>\n ) scores, and degree of anxiety by the State\u2010Trait Anxiety Inventory. Gastric motility was evaluated. Thirty\u2010four\n FD<\/jats:styled-content>\n patients were treated with nizatidine (300\u2009mg\/day) or placebo for 4 weeks in a crossover trial. The primary end point of this study was to determine whether nizatidine could improve clinical symptoms and sleep disorders in\n FD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The global\n PSQI<\/jats:styled-content>\n score for\n FD<\/jats:styled-content>\n patients was significantly (\n P<\/jats:italic>\n \u2009<\u20090.001) higher compared with healthy volunteers. There were significant correlations between global\n PSQI<\/jats:styled-content>\n scores and total Gastrointestinal Symptom Rating Scale and Self\u2010Rating Questionnaire for Depression scores (\n P<\/jats:italic>\n \u2009<\u20090.001,\n P<\/jats:italic>\n \u2009<\u20090.0001, respectively) in\n FD<\/jats:styled-content>\n patients than in healthy volunteers. We found significant relationships between subjective sleep quality and both\n T<\/jats:styled-content>\n max and\n T<\/jats:styled-content>\n 1\/2<\/jats:sub>\n values in\n FD<\/jats:styled-content>\n patients. Nizatidine significantly improved certain clinical symptoms, gastric emptying, and global\n PSQI<\/jats:styled-content>\n score compared with placebo treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Sleep disorders in\n FD<\/jats:styled-content>\n patients correlated significantly with both clinical symptoms of dyspepsia and depression compared with healthy volunteers. Nizatidine significantly improved gastroesophageal reflux symptoms, gastric emptying, and sleep disorders in\n FD<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12236","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T07:39:25Z","timestamp":1366702765000},"page":"1314-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Impact of sleep disorders in\n J<\/scp>\n apanese patients with functional dyspepsia (\n FD<\/scp>\n ): Nizatidine improves clinical symptoms, gastric emptying and sleep disorders in\n FD<\/scp>\n patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Seiji","family":"Futagami","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Nippon Medical School Tokyo 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