{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:46:31Z","timestamp":1779893191546,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T00:00:00Z","timestamp":1384819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor and Welfare"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nutritional factors play a key role in the pathogenesis of biliary diseases such as gallstones and pancreaticobiliary maljunction. Gallstones are primarily classified into cholesterol stone and pigment stone according to the major composition. Cholesterol gallstone formation is very likely based upon supersaturated bile formation, and pigment stones are formed in bile rich in bilirubin. Thus, defects of hepatic metabolism of lipids and organic anions lead to biliary stones. Here, the recent understanding of cholesterol gallstone pathogenesis is elaborated. On the other hand, there is another important link of biliary lipid degradation to serious biliary disease, namely pancreaticobiliary maljunction. Lysophosphatidylcholine (<jats:styled-content style=\"fixed-case\">lysoPC<\/jats:styled-content>), a derivative of phosphatidylcholine hydrolysis by phospholipase <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>2, is a highly abundant bioactive lipid mediator present in circulation as well as in bile. Increases in bile of <jats:styled-content style=\"fixed-case\">lysoPC<\/jats:styled-content> and phospholipase <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>2 have been reported in pancreaticobiliary maljunction and considered to be the major risk factor for biliary tract cancers. Further, oxidized fatty acids have been established as a potent ligand for <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>, a member of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> protein\u2010coupled receptor family that mediates a diverse array of biological processes including cell growth and apoptosis. Thus, both of <jats:styled-content style=\"fixed-case\">lysoPC<\/jats:styled-content> and free fatty acids are supposed to play an important role through <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> in biliary inflammation and carcinogenesis of pancreaticobiliary maljunction. Taken together, nutritional factors, especially lipid compounds, are seemingly crucial in the pathogenesis of biliary diseases, and such a causal relationship is reviewed by mainly authors\u2019 previous publications.<\/jats:p>","DOI":"10.1111\/jgh.12241","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T05:21:47Z","timestamp":1384924907000},"page":"103-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nutritional factors (nutritional aspects) in biliary disorders: Bile acid and lipid metabolism in gallstone diseases and pancreaticobiliary maljunction"],"prefix":"10.1111","volume":"28","author":[{"given":"Susumu","family":"Tazuma","sequence":"first","affiliation":[{"name":"Programs of Applied Medicine Clinical Pharmacotherapy Department of General Internal Medicine Hiroshima University Hospital Graduate School of Medical Science  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Kanno","sequence":"additional","affiliation":[{"name":"Programs of Applied Medicine Clinical Pharmacotherapy Department of General Internal Medicine Hiroshima University Hospital Graduate School of Medical Science  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Programs of Applied Medicine Clinical Pharmacotherapy Department of General Internal Medicine Hiroshima University Hospital Graduate School of Medical Science  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobusuke","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Programs of Applied Medicine Clinical Pharmacotherapy Department of General Internal Medicine Hiroshima University Hospital Graduate School of Medical Science  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.05.009"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200205000-00011"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.07.075"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1702-0"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(94)90093-0"},{"issue":"1","key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/bj3180139","article-title":"Lecithin hydrophobicity modulates the process of cholesterol crystal nucleation and growth in supersaturated model bile systems","volume":"318","author":"Ochi H","year":"1996","journal-title":"Biochem. J."},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309096059"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005524624411"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91432-7"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316801"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3400445"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3590605"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00156.2003"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200297-JLR200"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005695109908"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(03)00060-X"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(01)00173-1"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02347567"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199806000-00015"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(98)80057-X"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90138-8"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(05)80030-X"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.12.211"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0395-215"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20878"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004230100220"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000007869.67105.27"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.07.005"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2467-2"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(02)00170-5"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1432-0"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1995.tb01045.x"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05073.x"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.12.009"},{"issue":"5","key":"e_1_2_4_36_1","first-page":"G835","article-title":"Protection against hydrophobic bile salt\u2010induced cell membrane damage by liposomes and hydrophilic bile salts","volume":"264","author":"Sagawa H","year":"1993","journal-title":"Am. J. Physiol."},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.7.2052"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12241","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T05:59:49Z","timestamp":1694498389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,19]]},"references-count":36,"journal-issue":{"issue":"S4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/jgh.12241"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12241","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,19]]},"assertion":[{"value":"2013-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}