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In addition, <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is a risk factor for the development of other serious diseases, such as diabetes or cardiovascular disease. Therefore, the detection of early\u2010stage <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is important. Many studies have described the factors that predict the presence of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> and its onset, and several markers have been identified. These markers have enabled the identification of high\u2010risk patients and have improved routine medical practice. To prevent advanced disease, clinicians need to have simple markers that predict the onset of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> so that interventions can be started at much earlier stages of disease. This review summarizes the current state of knowledge regarding independent factors, as reported in large studies, that predict the presence of <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> and its onset, especially markers that can be used in daily medical practice, such as physical measurements and blood tests.<\/jats:p>","DOI":"10.1111\/jgh.12251","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T05:21:47Z","timestamp":1384924907000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Non\u2010alcoholic fatty liver disease: Factors associated with its presence and onset"],"prefix":"10.1111","volume":"28","author":[{"given":"Teruki","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teru","family":"Kumagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Tokumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Hiasa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunzo","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morikazu","family":"Onji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50161"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1844"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36572"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1475-x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00099-5"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i10.1579"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1991"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6891"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0311-8"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24491"},{"key":"e_1_2_14_12_1","first-page":"1","article-title":"Ideal body weight estimated from the body mass index with the lowest morbidity","volume":"15","author":"Tokunaga K","year":"1991","journal-title":"Int. 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