{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:43:31Z","timestamp":1790617411928,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["5\/4\/3-2\/2008-NCD-II"],"award-info":[{"award-number":["5\/4\/3-2\/2008-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Lactose malabsorption (\n LM<\/jats:styled-content>\n ), diagnosed currently using lactose hydrogen breath and tolerance tests (\n LHBT<\/jats:styled-content>\n ,\n LTT<\/jats:styled-content>\n ) with a high, nonphysiological dose (50\u2010g), may mimic irritable bowel syndrome (\n IBS<\/jats:styled-content>\n ). In\n LM<\/jats:styled-content>\n \u2010endemic areas, clinically significant malabsorption (lactose intolerance) may be better diagnosed using a lesser dose, and positive results so obtained may predict response to milk withdrawal more effectively.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifty patients each with\n IBS<\/jats:styled-content>\n (Rome\n III<\/jats:styled-content>\n ) were evaluated using\n LHBT<\/jats:styled-content>\n and\n LTT<\/jats:styled-content>\n with 50\u2010g, 25\u2010g, and 12\u2010g lactose. Sensitivity and specificity of\n LHBT<\/jats:styled-content>\n and\n LTT<\/jats:styled-content>\n with different dosages (gold standard: lactase gene\n C<\/jats:styled-content>\n \/\n T<\/jats:styled-content>\n \u201013910 polymorphism) and symptom development were evaluated. Effect of milk withdrawal was studied.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n Of 150 patients, 37\/50 (74%) and 28\/50 (56%) had\n LM<\/jats:styled-content>\n by\n LHBT<\/jats:styled-content>\n and\n LTT<\/jats:styled-content>\n using 50\u2010g lactose; 41\/50 (82%) and 31\/50 (62%) had\n LM<\/jats:styled-content>\n using 25\u2010g lactose, and 14\/50 (28%) and 29\/50 (58%) using 12\u2010g lactose, respectively. Sensitivity and specificity of\n LHBT<\/jats:styled-content>\n using 50\u2010g, 25\u2010g, and 12\u2010g lactose were 92.6%, 52.0%, and 94%, 60%, and 36.4%, 88.2%, and those of\n LTT<\/jats:styled-content>\n , 92%, 80.0%, and 84.8%, 82.4%, and 66.7%, 58.8%, respectively. Breath hydrogen correlated with lactose dose. Though patients developing symptoms with 50\u2010g lactose exhaled more hydrogen than those remaining asymptomatic, hydrogen levels did not differ following 25\u2010g and 12\u2010g dosages in relation to symptom development. Patients' milk intake was 335\u2009\u00b1\u200992\u2009mL\/d (\u2248\u200916.7\u2009\u00b1\u20099.6\u2010g lactose). Positive\n LHBT<\/jats:styled-content>\n using 25\u2010g dose better predicted symptom resolution than by 50\u2010g and 12\u2010g lactose.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Twenty\u2010five gram is the ideal dose of lactose for\n LHBT<\/jats:styled-content>\n and\n LTT<\/jats:styled-content>\n in\n LM<\/jats:styled-content>\n \u2010endemic areas.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12273","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T07:56:40Z","timestamp":1369209400000},"page":"1462-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lactose malabsorption diagnosed by 50\u2010g dose is inferior to assess clinical intolerance and to predict response to milk withdrawal than 25\u2010g dose in an endemic area"],"prefix":"10.1111","volume":"28","author":[{"given":"Uday C","family":"Ghoshal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balraj","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27946"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04986.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072952"},{"key":"e_1_2_6_5_1","first-page":"255","article-title":"Distribution of the adult lactase phenotypes in Turkey","volume":"38","author":"Flatz G","year":"1986","journal-title":"Trop. 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