{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:53:19Z","timestamp":1780116799819,"version":"3.54.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>For years, the natural course of diverticulitis in the young has been debatable in terms of its severity and recurrence rate, and no consensus has been reached regarding its treatment and timing of surgery. Thus, the study aims to evaluate by meta\u2010analysis the natural course of acute diverticulitis in the young.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from electronic databases and manual search of studies comparing the course of diverticulitis in young <jats:italic>versus<\/jats:italic> elderly patients. The age cut\u2010off was selected to be 40\u201350 years, and only studies using computed tomography as the sole modality for diagnosis were included. Primary outcomes were surgery during hospitalization and disease recurrence. Relative risks (<jats:styled-content style=\"fixed-case\">RRs<\/jats:styled-content>) with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) are reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand eighty publications were found, 12 of which were included. The total number of patients was 4982. Most young patients were males (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.70, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.31\u20132.21), without tendency toward a more complicated disease at admission (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.95, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.46\u20131.97). While there was no significant difference in the rate of surgery during hospitalization (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 0.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.46\u20131.06), young patients underwent more elective surgeries (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 2.39, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.82\u20133.15). No mortality was recorded among young patients. The disease recurrence rate was significantly higher than that of elderly patients (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.70, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.31\u20132.21); however, no study specified the mean follow\u2010up period for each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The course of diverticulitis in the young is not more severe than that in elderly patients; however, the disease tends to recur more often. Therefore, while choosing a therapeutic regimen, factors other than age should also be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12274","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T11:56:45Z","timestamp":1369223805000},"page":"1274-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Diverticulitis in the young is not more aggressive than in the elderly, but it tends to recur more often: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Lior H","family":"Katz","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center, Tel\u2010Hashomer  Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D","family":"Guy","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Lahat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center, Tel\u2010Hashomer  Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter\u2010Gvili","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Medicine E Beilinson Hospital Rabin Medical Center  Petach\u2010Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bar\u2010Meir","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sheba Medical Center, Tel\u2010Hashomer  Ramat\u2010Gan Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-3840(00)80011-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198002073020605"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5089(21)00097-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5089(21)00094-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198410000-00008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02258291"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41154.x"},{"key":"e_1_2_6_9_1","first-page":"117","article-title":"Long term outcome of patients presenting with acute complications of diverticular disease","volume":"76","author":"Sarin S","year":"1994","journal-title":"Ann. R. Coll. Surg. Eng."},{"key":"e_1_2_6_10_1","first-page":"156","article-title":"Acute left colonic diverticulitis in young patients","volume":"179","author":"Ambrosetti P","year":"1994","journal-title":"J. Am. Coll. Surg."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)81177-8"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"Divertular disease in the young patient","volume":"156","author":"Ouriel K","year":"1983","journal-title":"Surg. Gynecol. Obstet."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02560326"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)44479-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480106700516"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1177\/000313480206801203","article-title":"Acute diverticulitis in the young adult is not \u201cvirulent\u201d","volume":"68","author":"Schweitzer J","year":"2002","journal-title":"Am. Surg."},{"key":"e_1_2_6_17_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS)","author":"Wells GA","year":"2013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0546-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7723"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i2.207"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181c18d64"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181c3808c"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.01866.x"},{"key":"e_1_2_6_24_1","first-page":"1382","article-title":"Acute sigmoid diverticulitis in young patients","volume":"56","author":"M\u00e4kel\u00e4 JT","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6137"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.10.019"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i18.2932"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0033"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.7.681"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.6.576"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.5.1821159"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2003.08.022"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1861-4"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02195.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237300"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1457-2"},{"key":"e_1_2_6_37_1","first-page":"605","article-title":"Colonic diverticular disease in patients 40 years old or younger","volume":"58","author":"Acosta JA","year":"1992","journal-title":"Am. Surg."},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5703"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055381"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649901007"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4873"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200506000-00009"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000184843.89836.35"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.07.029"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4035"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-001-9236-x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-003-8809-2"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3182028576"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T12:17:59Z","timestamp":1713961079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,22]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/jgh.12274"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12274","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,22]]},"assertion":[{"value":"2013-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}