{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:37:38Z","timestamp":1778686658908,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"crossref","award":["NSC 101-2314-B-303-005-MY3"],"award-info":[{"award-number":["NSC 101-2314-B-303-005-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We aimed to evaluate whether acute esophageal instillation of capsaicin and hydrochloric acid had different effects on distension\u2010induced secondary peristalsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Secondary peristalsis was induced by slow and rapid air injections into the mid\u2010esophagus after the evaluation of baseline motility in 16 healthy subjects. The effects on secondary peristalsis were determined by esophageal instillation with capsaicin\u2010containing red pepper sauce (pure capsaicin, 0.84\u2009mg) and hydrochloric acid (0.1\u2009N).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The administration of capsaicin induced a significant increase in the visual analogue scale score for heartburn as compared with hydrochloric acid (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). The threshold volume for generating secondary peristalsis during slow and rapid air distensions did not differ between capsaicin and hydrochloric acid infusions. Hydrochloric acid significantly increased the frequency of secondary peristalsis in response to rapid air distension compared with capsaicin infusion (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Pressure wave amplitude during slow air distension was greater with the infusion of hydrochloric acid than capsaicin infusion (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). The pressure wave duration during rapid air distension was longer after capsaicin infusion than hydrochloric acid infusion (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). The pressure wave amplitude during rapid air distension was similar between capsaicin and hydrochloric acid infusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite subtle differences in physiological characteristics of secondary peristalsis, acute esophageal instillation of capsaicin and hydrochloric acid produced comparable effects on distension\u2010induced secondary peristalsis. Our data suggest the coexistence of both acid\u2010 and capsaicin\u2010sensitive afferents in human esophagus which produce similar physiological alterations in secondary peristalsis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12284","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T10:52:57Z","timestamp":1370343177000},"page":"1712-1716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparable effects of capsaicin\u2010containing red pepper sauce and hydrochloric acid on secondary peristalsis in humans"],"prefix":"10.1111","volume":"28","author":[{"given":"Chien\u2010Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medicine Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hsun","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Medicine Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tso\u2010Tsai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Buddhist Tzu Chi General Hospital and Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90012-N"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105998"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.5.G1246"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014593"},{"key":"e_1_2_6_6_1","first-page":"G927","article-title":"Initiation of esophageal secondary peristalsis by slow fluid infusion in the opossum: effect of hydrochloric acid","volume":"270","author":"Kusano M","year":"1996","journal-title":"Am. 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