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This study aims to evaluate the diagnostic value of\n qHBsAg<\/jats:styled-content>\n for hepatic fibrosis in hepatitis\n B<\/jats:styled-content>\n e antigen (\n HBeAg<\/jats:styled-content>\n )\u2010positive\n HBV<\/jats:styled-content>\n carriers.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Consecutive biopsy\u2010proven\n HBeAg<\/jats:styled-content>\n \u2010positive\n HBV<\/jats:styled-content>\n carriers were prospectively recruited in our center from 2009 to 2011 and were randomly divided into training and validation set. Area under receiver\u2010operator curve (\n AUC<\/jats:styled-content>\n ) was used to determine the diagnostic accuracy of simple tests for significant fibrosis (\n S<\/jats:styled-content>\n cheuer stage,\n F<\/jats:styled-content>\n \u2009\u2265\u20092).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, a total of 197 eligible patients (median age 31 years; 149 males) were enrolled. The median\n qHBsAg<\/jats:styled-content>\n was 4.20 (log\n 10<\/jats:sub>\n IU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n ). Significant fibrosis was confirmed in 112 (56.9%) patients. By logistical regression analysis,\n qHBsAg<\/jats:styled-content>\n and \u03b3\u2010glutamyl transpeptidase were identified as predictors for significant fibrosis in training set (\n n<\/jats:italic>\n \u2009=\u2009124). Thus,\n qHBsAg<\/jats:styled-content>\n index and \u03b3\u2010glutamyl transpeptidase to\n qHBsAg<\/jats:styled-content>\n ratio (\n GqHBsR<\/jats:styled-content>\n ) were selected for the subsequent analysis. In the training set, an\n AUC<\/jats:styled-content>\n of 0.762, 0.826, 0.749, and 0.771 was observed for\n qHBsAg<\/jats:styled-content>\n index,\n GqHBsR<\/jats:styled-content>\n ,\n FIB<\/jats:styled-content>\n \u20104, and aspartate aminotransferase to platelet ratio index, respectively (all\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u20090.05).\n GqHBsR<\/jats:styled-content>\n yielded a higher\n AUC<\/jats:styled-content>\n than aspartate aminotransferase to platelet ratio index and\n FIB<\/jats:styled-content>\n \u20104 (both\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u2009<\u20090.05). Using the optimal cut\u2010off of 7.78,\n GqHBsR<\/jats:styled-content>\n showed a sensitivity of 78.9% and a specificity of 73.6%. About 80% of liver biopsy could be avoided in the entire cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Serum\n qHBsAg<\/jats:styled-content>\n \u2010based simple tests, especially\n GqHBsR<\/jats:styled-content>\n , can accurately and specifically identify significant fibrosis in treatment\u2010na\u00efve\n HBeAg<\/jats:styled-content>\n \u2010positive\n HBV<\/jats:styled-content>\n carriers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12304","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T21:26:43Z","timestamp":1372195603000},"page":"1746-1755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Serum hepatitis\n B<\/scp>\n surface antigen quantification as a useful assessment for significant fibrosis in hepatitis\n B<\/scp>\n e antigen\u2010positive hepatitis\n B<\/scp>\n virus carriers"],"prefix":"10.1111","volume":"28","author":[{"given":"Yun\u2010hao","family":"Xun","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai China"},{"name":"Department of Liver Diseases The Sixth People's Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010qing","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010chun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases The Sixth People's Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases The Sixth People's Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases The Sixth People's Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Liver Diseases The Sixth People's Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou Zhejiang China"},{"name":"Department of Liver Disease The Affiliated Hospital of Hangzhou Normal University 126 Wenzhou Road Hangzhou 310015 Zhejiang Province 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