{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:59:48Z","timestamp":1792166388322,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Stress is believed to play a role in the pathogenesis of functional gastrointestinal disorders. The aim of the present study was to investigate the effect of acute auditory stress on gastric motor responses to a meal in healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of eight healthy volunteers (seven men and one woman; median age, 33.4 years [30\u201335 years]) who had no recurrent gastrointestinal symptoms participated in the prospective, randomized, crossover study. Gastric half\u2010emptying time and meal\u2010induced proximal gastric accommodation were measured using gastric scintigraphy under the auditory stress and control conditions in a randomized crossover design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gastric half\u2010emptying time under the stress condition was significantly longer than that under the control condition (130.8\u2009\u00b1\u200916.6 <jats:italic>vs<\/jats:italic> 105.0\u2009\u00b1\u200913.1\u2009min; <jats:italic>P<\/jats:italic>\u2009=\u20090.005 by paired <jats:italic>t<\/jats:italic>\u2010test). Under the stress and control conditions, the proximal gastric volume significantly increased after a meal (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 by repeated measures analysis of variance). The degree of the postprandial increase in proximal gastric volume did not significantly differ between both conditions (<jats:italic>P<\/jats:italic>\u2009=\u20090.598 by tests of between\u2010subjects effects using repeated measures analysis of variance). The severity scores of postprandial epigastric discomfort and fullness were significantly higher under the stress condition than under the control condition (<jats:italic>P<\/jats:italic>\u2009=\u20090.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.039, respectively, by paired <jats:italic>t<\/jats:italic>\u2010test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute auditory stress delays gastric emptying and increases the severity of postprandial symptoms in the healthy subjects, suggesting the relevance of psychological stress to the pathophysiological mechanism of functional dyspepsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12309","type":"journal-article","created":{"date-parts":[[2013,6,26]],"date-time":"2013-06-26T01:26:47Z","timestamp":1372210007000},"page":"1699-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The effect of acute auditory stress on gastric motor responses to a meal in healthy volunteers"],"prefix":"10.1111","volume":"28","author":[{"given":"Hong Sub","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Sil","family":"An","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonkoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hwan","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000156109.97999.d1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050681"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.368"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00499.2004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)91678-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30085"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90412-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.4.277"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80233-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(82)80128-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.24.3.236"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199004000-00011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)01008-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.12.010"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07156.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00497.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.277.6.G1217"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05264.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.781"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02349.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2006.09.007"},{"key":"e_1_2_6_25_1","first-page":"11","article-title":"Determination of cortisol in saliva and serum by a luminescence\u2010enhanced enzyme immunoassay","volume":"50","author":"Westermann J","year":"2004","journal-title":"Clin. 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