{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:57:43Z","timestamp":1785326263075,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Risk factors for acute variceal bleeding in patients with hepatocellular carcinoma (HCC<\/jats:styled-content>) and concurrent main portal vein thrombosis (PVT<\/jats:styled-content>) remain unclear. We aimed to determine risk factors of in\u2010hospital mortality after acute variceal bleeding for HCC<\/jats:styled-content> patients with concurrent main PVT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a retrospective analysis of 102 HCC<\/jats:styled-content> patients (83% men and 17% women) with concurrent main PVT<\/jats:styled-content> and acute variceal bleeding. All patients received emergent endoscopy to define the bleeding source. Multivariable Cox proportional hazard regression analysis consisting of clinical, laboratory, and endoscopic parameters was performed to identify predictive factors for intrahospital mortality.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010eight (27.5%) patients died within admission. The median survival of all patients was 56 days. Multivariable Cox proportional hazard regression analyses revealed Child\u2010Pugh score (adjusted hazard ratio [aHR<\/jats:styled-content>]: 1.29 for each point; 95% confidence interval [CI<\/jats:styled-content>]: 1.11\u20131.50), active bleeding on index endoscopy (aHR<\/jats:styled-content>: 7.50; 95% CI<\/jats:styled-content>: 3.05\u201318.4), esophageal varices as the bleeder (compared with gastric varices, aHR: 14.3; 95% CI<\/jats:styled-content>: 3.12\u201366.1), failure to control bleeding (aHR<\/jats:styled-content>: 38.0; 95% CI<\/jats:styled-content>: 7.44\u2013194), and serum creatinine (aHR<\/jats:styled-content>: 1.28 for each increase of 1\u2009mg\/dL; 95% CI<\/jats:styled-content>: 1.09\u20131.50) independently predicted in\u2010hospital mortality.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Hepatic reserve, active bleeding on index endoscopy, failure to control bleeding, esophageal varices as the bleeder when compared with gastric varices, and renal function were independent predictive factors for in\u2010hospital mortality in HCC<\/jats:styled-content> patients with acute variceal bleeding and concurrent main PVT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12341","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T10:28:52Z","timestamp":1374488932000},"page":"344-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predictors of in\u2010hospital mortality after acute variceal bleeding in patients with hepatocellular carcinoma and concurrent main portal vein thrombosis"],"prefix":"10.1111","volume":"29","author":[{"given":"Ming\u2010Lun","family":"Han","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Min\u2010Sheng General Hospital Taoyan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh\u2010Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Yun\u2010Lin County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hao","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Yun\u2010Lin Branch Yun\u2010Lin County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Feng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Hsin\u2010Chu Branch Hsin\u2010Chu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh\u2010Ming","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Shiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70186-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20339"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(89)72701-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04418.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02774339"},{"issue":"3","key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF02779259","article-title":"Clinical evaluation of endoscopic injection sclerotherapy for bleeding esophageal varices in liver cirrhosis with hepatocellular carcinoma","volume":"26","author":"Nakashima M","year":"1991","journal-title":"Gastroenterol. 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