{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:05:19Z","timestamp":1782299119159,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>To identify predictive factors related to the development of erythema nodosum and pyoderma gangrenosum, in patients with inflammatory bowel disease (IBD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Epidemiological and clinical data from 270 patients with C<\/jats:styled-content>rohn's disease (CD<\/jats:styled-content>) and 125 patients with ulcerative colitis (UC<\/jats:styled-content>) were collected between 2003 and 2011. The variables retrospectively analyzed were: gender, age at diagnosis, type of IBD<\/jats:styled-content> (CD<\/jats:styled-content> or UC<\/jats:styled-content>), smoking habit, pattern of disease (IBD<\/jats:styled-content>), location and extension, family history, previous IBD<\/jats:styled-content>\u2010related surgery, other extraintestinal manifestations (EIMs<\/jats:styled-content>), and previous biological and immunosuppressive therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010seven patients showed at least one cutaneous manifestation. These lesions were more frequent in women (15.4%) than in men (4.2%; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0001) and in CD<\/jats:styled-content> (12.2%) than in UC<\/jats:styled-content> patients (3.2%; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.005). These manifestations were more frequently associated with other EIMs<\/jats:styled-content> (25% vs<\/jats:italic> 7.2%; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0001), and they were less frequent in patients who received a previous biological therapy for IBD<\/jats:styled-content> (6.8% vs<\/jats:italic> 11.2%; P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.1). Patients with skin manifestations were younger at diagnosis of IBD<\/jats:styled-content> than those patients without them (26.3\u2009\u00b1\u200910 vs<\/jats:italic> 32.9\u2009\u00b1\u200914.5, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.008). Independent variables significantly associated with development of skin manifestations were: female (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.008), previous biological therapy (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.007), age at diagnosis (young, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.026), type of IBD<\/jats:styled-content> (CD<\/jats:styled-content>, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.043) and presence of other EIMs<\/jats:styled-content> (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Predictive factors involved in the development of main cutaneous manifestations are: female, CD<\/jats:styled-content>, young age at diagnosis of IBD<\/jats:styled-content>, and presence of other EIMs<\/jats:styled-content>. Early use of biological therapies prevents the development of cutaneous manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12352","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T15:21:32Z","timestamp":1375975292000},"page":"291-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Predictive factors for erythema nodosum and pyoderma gangrenosum in inflammatory bowel disease"],"prefix":"10.1111","volume":"29","author":[{"given":"Javier","family":"Ampuero","sequence":"first","affiliation":[{"name":"Unit for Clinical Management of Digestive Diseases Valme University Hospital Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Rojas\u2010Feria","sequence":"additional","affiliation":[{"name":"Unit for Clinical Management of Digestive Diseases Valme University Hospital Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Castro\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unit for Clinical Management of Digestive Diseases Valme University Hospital Sevilla Spain"},{"name":"Networked Biomedical Research Center in Hepatic and Digestive Diseases (CIBERehd) Valme University Hospital Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cano","sequence":"additional","affiliation":[{"name":"Unit for Clinical Management of Digestive Diseases Valme University Hospital Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Romero\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Unit for Clinical Management of Digestive Diseases Valme University Hospital Sevilla Spain"},{"name":"Networked Biomedical Research Center in Hepatic and Digestive Diseases (CIBERehd) Valme University Hospital Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(01)00002-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03756.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02055.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.02.020"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5070\/D34829T6RN","article-title":"Erythema nodosum","volume":"8","author":"Requena L","year":"2002","journal-title":"Dermatol. 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