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Most of the liver injury is associating with inflammatory cytokines. Resveratrol (RSV<\/jats:styled-content>) is a natural phytoalexin with powerful anti\u2010inflammatory effects.<\/jats:p><\/jats:sec>Aim<\/jats:title>The effects of RSV<\/jats:styled-content> on cellular factors mediating liver damage and regeneration in acute carbon tetrachloride (CCl4<\/jats:sub><\/jats:roman><\/jats:styled-content>) liver injury were investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>RSV<\/jats:styled-content> decreased alanine aminotransferase, aspartate aminotransferase, necrosis, and 4\u2010hydroxynonenal in the CCl4<\/jats:sub><\/jats:roman><\/jats:styled-content>\u2010injured liver. RSV<\/jats:styled-content> decreased hepatocyte apoptosis by reducing caspase 8 and caspase 3 but not Bax<\/jats:styled-content> and Bcl\u2010xL<\/jats:styled-content>. RSV<\/jats:styled-content> reduced K<\/jats:styled-content>upffer cells recruitment, the expressions of tumor necrosis factor\u2010\u03b1 and interleukin\u20106, but not interleukin\u201010. RSV<\/jats:styled-content> lowered the numbers of anti\u20105\u2010bromon\u20102'\u2010deoxyuridine and anti\u2010K<\/jats:styled-content>i67\u2010positive hepatocytes. Hepatic hepatocyte growth factor, c\u2010M<\/jats:styled-content>et and transforming growth factor\u2010\u03b1 expressions were reduced by RSV<\/jats:styled-content>, while transforming growth factor\u2010\u03b21 and hepatic stellate cells activation were not changed. RSV<\/jats:styled-content> reduced the injury\u2010induced CXCL<\/jats:styled-content>10 elevations in serum and liver in vivo<\/jats:italic>. Besides, RSV<\/jats:styled-content> inhibited CXCL<\/jats:styled-content>10 release from CCl4<\/jats:sub><\/jats:roman><\/jats:styled-content>\u2010injured hepatocytes in vitro<\/jats:italic>. In contrast, recombinant CXCL<\/jats:styled-content>10 improved the viability of CCl4<\/jats:sub><\/jats:roman><\/jats:styled-content>\u2010injured hepatocytes.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>RSV<\/jats:styled-content> therapy can be beneficial for acute toxic liver injury. RSV<\/jats:styled-content> reduced hepatocyte apoptosis but limited hepatocyte regeneration possibly through reducing the hepatomitogenic signaling and the release of CXCL<\/jats:styled-content>10.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12366","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T11:18:43Z","timestamp":1377256723000},"page":"603-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury"],"prefix":"10.1111","volume":"29","author":[{"given":"Che\u2010Chang","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang\u2010Ming University School of Medicine Institute of Clinical Medicine Taipei 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